T6830
Thyroglobulin human
Synonym(s):
Thyroglobulin human
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About This Item
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biological source
human
Assay
≥95% (SDS-PAGE)
form
lyophilized solid
technique(s)
cell culture | mammalian: suitable
UniProt accession no.
storage temp.
2-8°C
Gene Information
human ... TG(7038)
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General description
Human Thyroglobulin (Tg) is a 660 kDa, dimeric protein produced by and used entirely within the thyroid gland. Human Thyroglobin is used by the thyroid gland to produce the thyroid hormones thyroxine (T4) and triiodothyryonine. Patients with Hashimoto′s thyroiditis or Grave′s disease, frequently develop antibodies against human Thyroglobulin.
Human Thyroglobulin (Tg) is a 660 kDa, dimeric protein produced by and used entirely within the thyroid gland. Human Thyroglobin is used by the thyroid gland to produce the thyroid hormones thyroxine (T4) and triiodothyryonine. Patients with Hashimoto′s thyroiditis or Graves′ disease, frequently develop antibodies against human Thyroglobulin. Thryoglobulin levels in the blood can be used as a tumor marker for certain kinds of thyroid cancer and in Graves′ disease.
Biochem/physiol Actions
Thyroglobulin has been shown to induce expression of platelet activating factor in human peripheral blood mononuclear cells which is found elevated in some patients with thyroid disease.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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E Resetkova et al.
Regional immunology, 4(4), 204-208 (1992-07-01)
Platelet activating factor (PAF), a phospholipid mediator, has been found to play a role in immune reactions, as well as in many pathophysiological alterations in certain disorders. To determine whether there might be a potential role of PAF in the
Ricardo Adaixo et al.
Nature communications, 13(1), 61-61 (2022-01-12)
The thyroglobulin (TG) protein is essential to thyroid hormone synthesis, plays a vital role in the regulation of metabolism, development and growth and serves as intraglandular iodine storage. Its architecture is conserved among vertebrates. Synthesis of triiodothyronine (T3) and thyroxine
Fiona L R Williams et al.
The Journal of clinical endocrinology and metabolism, 98(2), 829-838 (2013-01-17)
Relatively little is known in euthyroid populations about the changes in maternal thyroid hormones during pregnancy, the nature of the relationship to cord thyroid hormone levels, and subsequent infant neurodevelopment. The aim of the study was to describe the relationship
Stine L Andersen et al.
European journal of endocrinology, 168(5), 723-731 (2013-02-28)
Placental transport of iodide is required for fetal thyroid hormone production. The sodium iodide symporter (NIS) mediates active iodide transport into the thyroid and the lactating mammary gland and is also present in placenta. NIS is competitively inhibited by thiocyanate
Andrew N Hoofnagle et al.
The Journal of clinical endocrinology and metabolism, 98(4), 1343-1352 (2013-03-02)
Serum thyroglobulin (Tg) measurements are central to the management of patients treated for differentiated thyroid carcinoma. For decades, Tg measurements have relied on methods that are subject to interference by commonly found substances in human serum and plasma, such as
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