SML0005

Cerivastatin sodium salt hydrate

≥98% (HPLC)

• 동의어(들): (3R,5S,6E)-7-[4-(4-Fluorophenyl)-5-(methoxymethyl)-2,6-bis(1-methylethyl)-3-pyridinyl]-3,5-dihydroxy-6-heptenoic acid sodium salt hydrate, Rivastatin hydrate
• 실험식(Hill 표기법): C₂₆H₃₃FNNaO₅ · xH₂O
• CAS Number: 143201-11-0
• Molecular Weight: 481.53 (anhydrous basis)
• MDL number: MFCD20488047
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329825082
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 광학 활성: [α]/D +18 to +26° in ethanol
• 저장 조건: desiccated
• 색상: white to tan
• solubility: H₂O: ≥5 mg/mL
• 주관자: Bayer
• 저장 온도: 2-8°C
• SMILES string: O.[Na+].COCc1c(nc(C(C)C)c(\C=C\[C@@H](O)C[C@@H](O)CC([O-])=O)c1-c2ccc(F)cc2)C(C)C
• InChI: 1S/C26H34FNO5.Na.H2O/c1-15(2)25-21(11-10-19(29)12-20(30)13-23(31)32)24(17-6-8-18(27)9-7-17)22(14-33-5)26(28-25)16(3)4;;/h6-11,15-16,19-20,29-30H,12-14H2,1-5H3,(H,31,32);;1H2/q;+1;/p-1/b11-10+;;/t19-,20-;;/m1../s1
• InChI key: NJHMEKXCHXHQPP-PZLZTSNUSA-M

설명

일반 설명

Cerivastatin sodium salt hydrate belongs to the statin class of lipid lowering agents.[1] It helps in decreasing MAP kinase activation, blocking AP-1 (activator protein-1) and NF-kB (nuclear factor-kB ) binding activity, inhibiting inflammatory responses and ameliorated renal damage. It also lowers cholesterol.[2] It is metabolized by cytochrome P450 (CYP)3A4 and (CYP)2C8.[1] Cerivastatin sodium salt hydrate is linked to rhabdomyolysis.[3]

애플리케이션

Cerivastatin sodium salt hydrate has been used as a supplement in cell culture.[4]

Cerivastatin sodium salt hydrate may be used in cell signaling studies.

생화학적/생리학적 작용

Accumulated macrophages in atherosclerotic plaques result in plaque rupture and thrombus formation. Cerivastatin suppresses the growth of macrophages and decreases the expression of matrix metalloproteinases and tissue factor molecules, thus reduces acute coronary events.[5][6]

Cerivastatin sodium is an HMG-CoA reductase inhibitor. HMG-CoA is a key enzyme in the production of cholesterol.

HMG-CoA reductase inhibitor

특징 및 장점

This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable