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Merck
모든 사진(1)

주요 문서

T5530

Sigma-Aldrich

ANTI-TAU (MAPT) Antibody

mouse monoclonal, TAU-2

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0.2 ML
₩1,121,474

₩1,121,474


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0.2 ML
₩1,121,474

About This Item

MDL number:
UNSPSC 코드:
12352203
NACRES:
NA.41

₩1,121,474


구입 가능 여부는 고객센터에 문의하십시오.

벌크 견적 요청

제품명

Monoclonal Anti-τ (Tau) antibody produced in mouse, clone TAU-2, ascites fluid

생물학적 소스

mouse

Quality Level

결합

unconjugated

항체 형태

ascites fluid

항체 생산 유형

primary antibodies

클론

TAU-2, monoclonal

분자량

antigen 55-62 kDa

포함

15 mM sodium azide

종 반응성

monkey, bovine, chicken, human

기술

immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
microarray: suitable
western blot: 1:1,000 using a fresh total bovine brain extract or an enriched microtubule protein preparation

동형

IgG1

UniProt 수납 번호

배송 상태

dry ice

저장 온도

−20°C

타겟 번역 후 변형

unmodified

유전자 정보

human ... MAPT(4137)

관련 카테고리

일반 설명

Monoclonal Anti- τ (TAU) (mouse IgG1 isotype) is derived from the hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse. τ (TAU) proteins are a part of microtubule associated proteins (MAPs). They are densely found in neurons and in trace amounts in non-neuronal cells. In brain six isoforms of τ (TAU) proteins are present.
The antibody reacts exclusively with the chemically heterogeneous τ in both the phosphorylated and non-phosphorylated form. The antibody does not react with other MAPs or with tubulin. In immunohistochemical staining, it localizes τ along microtubules in axons, somata, dendrites and astrocytes, and on ribosomes. The antibody may be used for staining of τ in Alzheimer neurofibrillary tangles in sections of human brain tissue.
The best known microtubule associated proteins (MAPs) which copurify with microtubules are MAP2 and Tau. These two proteins are heat stable and stimulate formation of the microtubule polymer from purified tubulin subunits. Tau is chemically heterogenous, however, limited protolysis has demonstrated that the different eletrophoretic species are closely related. Tau is immunologically distinct from the other MAPs, namely MAP1, MAP2 and MAP5. Localization studies have demonstrated that Tau is intimately associated with the filamentous structures which compose the neurofibrillary tangles as found in an Alzheimer′s disease brain.

면역원

bovine microtubule-associated proteins (MAPs)

애플리케이션

Monoclonal Anti-τ (Tau) antibody has been used:
  • in immunohistology
  • in immunoblotting
  • in dot blot
  • in immunohistochemistry

Mouse monoclonal clone TAU-2 anti-Tau antibody maybe used to study microtubule associated proteins (MAP) expression and cytological localization in various tissue and cell lines, under different developmental and environmental circumstances.

생화학적/생리학적 작용

Monoclonal Anti- τ (TAU) is phosphatase independent; it will bind Tau proteins in either their phosphorylated or non-phosphorylated forms. It localizes Tau proteins along microtubules in axons, somata, dendrites, astrocytes and on ribosomes (polysomes). The best-known microtubule associated proteins (MAPs) which copurify with microtubules are MAP2 and Tau. These two proteins are heat stable and stimulate formation of the microtubule polymer from purified tubulin subunits. Tau is immunologically distinct from the other MAPs. Tau is intimately associated with the filamentous structures which compose the neurofibrillary tangles as found in an Alzheimer′s disease brain.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


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문서 라이브러리 방문

Severity of gliosis in Pick?s disease and frontotemporal lobar degeneration: tau-positive glia differentiate these disorders
Schofield E, et al.
Brain, 126(4), 827-840 (2003)
R E Mrak et al.
Human pathology, 26(8), 816-823 (1995-08-01)
The roles of activated glia and of glial cytokines in the pathogenesis of Alzheimer's disease are reviewed. Interleukin-1 (IL-1), a microglia-derived acute phase cytokine, activates astrocytes and induces expression of the astrocyte-derived cytokine, S100 beta, which stimulates neurite growth (and
Cortical limb myoclonus in pathologically proven progressive supranuclear palsy.
Sharon Kemp et al.
Movement disorders : official journal of the Movement Disorder Society, 28(13), 1804-1806 (2013-10-15)
Chris R Guthrie et al.
Journal of molecular neuroscience : MN, 45(1), 32-41 (2011-02-23)
Lesions containing aggregated and hyperphosphorylated tau protein are characteristic of neurodegenerative tauopathies. We have developed a cellular model of pathological tau deposition and clearance by overexpressing wild type human tau in HEK293 cells. When proteasome activity is inhibited, HEK293/tau cells
Glenda M Halliday et al.
Brain : a journal of neurology, 128(Pt 10), 2272-2280 (2005-07-15)
Changes in motor cortical activation are associated with the major symptoms observed in both Parkinson's disease and progressive supranuclear palsy (PSP). While research has concentrated on basal ganglia abnormalities as central to these cortical changes, several studies in both disorders

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