M4403

Monoclonal Anti-MAP2 antibody produced in mouse

clone HM-2, ascites fluid

• 동의어(들): MAP2 Antibody - Monoclonal Anti-MAP2 antibody produced in mouse, Map2 Antibody
• MDL number: MFCD00164683
• UNSPSC 코드: 12352203
• NACRES: NA.41

속성

• 생물학적 소스: mouse
• Quality Level: 200
• 결합: unconjugated
• 항체 형태: ascites fluid
• 항체 생산 유형: primary antibodies
• 클론: HM-2, monoclonal
• 분자량: antigen ~280 kDa
• 포함: 15 mM sodium azide
• 종 반응성: rat, chicken, human, mouse, bovine, quail
• 기술: immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable; western blot: 1:1,000 using a fresh total rat brain extract or an enriched microtubule protein preparation
• 동형: IgG1
• UniProt 수납 번호: P11137
• 배송 상태: dry ice
• 저장 온도: −20°C
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... MAP2(4133) ; mouse ... Mtap2(17756) ; rat ... Map2(25595)

설명

일반 설명

Microtubule-associated protein 2 (MAP2) is a neuronal protein. It belongs to the MAP2/Tau family. This gene is located to human chromosome 2q34-q35. MAP2 is present in neurons. MAP2 is the major microtubule-associated protein of brain tissue. There are three forms of MAP2; two are similarly sized with apparent molecular weights of 280kDa (MAP2a and MAP2b) and the third with a lower molecular weight of 70kDa (MAP2c).

특이성

Reacts with all known forms of MAP2, namely MAP2a, MAP2b and MAP2c. Does not cross-react with other MAPs or tubulin. By immunohistochemical staining of formalin-fixed, paraffin-embedded brain tissue, the antibody shows selective labeling of dendritic trees throughout the brain.

면역원

rat brain microtubule-associated proteins (MAPs).

애플리케이션

Monoclonal Anti-MAP2 (2a+2b) antibody has been used in immunohistochemistry, immunostaining and western blotting.

생화학적/생리학적 작용

Microtubule-associated protein 2 (MAP2) interacts with microtubules to maintain the structure of dendrites. It plays a major role in supporting the actin cytoskeleton in spines, binding and nucleating filamentous actin (f-actin) to modulate spine morphology.

물리적 형태

Supplied as ascites fluid with 15 mM sodium azide as a preservative.

저장 및 안정성

For continuous use, store at 2-8 °C for up to one month. For extended storage, the solution may be frozen in working aliquots. Repeated freezing and thawing, or storage in "frost-free" freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: nwg
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable