T5425

Transforming Growth Factor-β3 human

TGF-β3, recombinant, expressed in baculovirus infected Sf21 cells, powder, suitable for cell culture

• 동의어(들): hTGF-β3, TGF-β3
• MDL number: MFCD00213054
• UNSPSC 코드: 12352202
• NACRES: NA.77

속성

• 생물학적 소스: human
• Quality Level: 100
• 재조합: expressed in baculovirus infected Sf21 cells
• 분석: ≥97% (SDS-PAGE)
• 형태: powder
• 효능: 0.01-0.09 ng/mL ED₅₀/EC₅₀
• 품질: endotoxin tested
• 분자량: predicted mol wt ~25 kDa
• 포장: pkg of 2 μg
• 저장 조건: avoid repeated freeze/thaw cycles
• 기술: cell culture | mammalian: suitable
• 불순물: <0.01 EU/μg
• UniProt 수납 번호: P10600
• 저장 온도: −20°C
• 유전자 정보: human ... TGFB3(7043)

설명

일반 설명

The TGFβ3 (transforming Growth Factor-β3) gene is mapped to human chromosome 14q24.3.

애플리케이션

Transforming Growth Factor-β3 human has been used to study the role of TGF-β3 in healing tendon-to-bone insertion and in chondrogenic differentiation.

생화학적/생리학적 작용

TGF-β (transforming growth factor-β3) isoforms are significantly involved in inducing inflammatory responses. It is associated with vascular diseases, wound healing and ameliorating effect in venous leg ulcer. TGF-β3 has an antagonistic effect on TGF-β1 and reduces the degree of collagen type I deposition and fibroblast differentiation. As a result TGF-β3 might lead to ulcer chronicity due to hindered myofibroblasts formation. TGF-β is a key player in tumor formation and progression. Increased TGF-β3 expression is observed in cancer and adipose tissue fibrosis. TGF-β3 is crucial in tissue regeneration and scarless tissue repair.

TGF-β3 is less prevalent in natural expression than either TGF-β1 or TGF-β2, but it is the most abundant mRNA expressed in chick embryos. It is also expressed in human umbilical cord, in a variety of mesenchymal cells of human and rodent origin, and in several human carcinoma cells.

물리적 형태

Lyophilized from a 0.2 μm filtered solution in 35% acetonitrile and 0.1% trifluoroacetic acid containing 50 μg bovine serum albumin per 1 μg of cytokine.

분석 메모

The biological activity is measured by its ability to inhibit the IL-4-dependent proliferation of mouse HT-2 cells.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)