추천 제품
생물학적 소스
human
Quality Level
재조합
expressed in HEK 293 cells
분석
≥95% (SDS-PAGE)
형태
lyophilized powder
효능
≤1.0 ng/mL EC50
품질
endotoxin tested
분자량
dimer 25 kDa (non-glycosylated)
포장
pkg of 5 μg
제조업체/상표
HumanZyme
저장 조건
avoid repeated freeze/thaw cycles
기술
cell culture | mammalian: suitable
불순물
≤1 EU/μg
UniProt 수납 번호
저장 온도
−20°C
유전자 정보
human ... TGFB3(7043)
유사한 제품을 찾으십니까? 방문 제품 비교 안내
일반 설명
TGF-β3 (transforming growth factor-β3) belongs to the TGF β superfamily. The TGFβ3 gene is mapped to human chromosome 14q24.3
생화학적/생리학적 작용
TGF-β3 (transforming growth factor-β3) regulates lymphocyte proliferation, apoptosis, hematopoiesis and embryogenesis to maintain immune homeostasis. TGF-β plays an important role in cell growth, differentiation, and survival. TGF-β3 specifically promotes chondrogenic differentiation.TGF-β3 is a strong growth inhibitor for normal and transformed epithelial, lymphoid, fibroblast, and keratinocyte cells. TGF-2 inhibits antitumor action of NK (natural killer) cells, T-cells, macrophages, monocytes and neutrophils. TGF-β3 is a tumor suppressor in the early stages of carcinogenesis, but in the later stages acts as a tumor promoter by inducing epithelial-mesenchymal transition and stimulating angiogenesis. TGF-β isoforms is known to participate in wound healing and tissue fibrosis. TGF-β3 is crucial for tissue restoration and scarless tissue repair. Mutation in the TGFβ3 gene is associated with development of non-syndromic cleft palate only (NS CPO), a rare congenital disease.
TGF-β3 is less prevalent in natural expression than either TGF-β1 or TGF-β2, but it is the most abundant mRNA expressed in chick embryos. It is also expressed in human umbilical cord, in a variety of mesenchymal cells of human and rodent origin, and in several human carcinoma cells.
물리적 형태
Lyophilized from a 0.2 μm filtered solution of 50 mM NaOAc pH 4.5
제조 메모
HumanKine TGF-β3 is expressed in human HEK 293 cells as a mature, disulfide linked, non- glycosylated homodimer with a predicted molecular mass of 25 kDa.
This product is lyophilized from a solution of 50mM NaOAc, pH 3.7.
This product is lyophilized from a solution of 50mM NaOAc, pH 3.7.
분석 메모
The specific activity was determined by the dose-dependent inhibition of IL-4 induced proliferation of mouse HT-2 cells (BALB/c spleen activated by sheep erythrocytes in the presence of IL-2).
법적 정보
HumanKine is a registered trademark of Proteintech Group, Inc. and Humanzyme, Inc
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
이미 열람한 고객
Hongbin Fan et al.
Journal of biomedical materials research. Part A, 95(4), 982-992 (2010-09-28)
Although most in vitro studies indicate that transforming growth factor β3 (TGF-β3) immobilized scaffold is suitable for cartilage tissue engineering, in vivo studies of implanting immobilized scaffold for chondral defect repair are still lacking. This study is to evaluate the
Adipose tissue fibrosis in human cancer cachexia: the role of TGFβ pathway.
Alves MJ, et al.
BMC Cancer, 17(1) (2017)
Curcumin suppresses doxorubicin-induced epithelial-mesenchymal transition via the inhibition of TGF-β and PI3K/AKT signaling pathways in triple-negative breast cancer cells.
Chen WC, et al.
Journal of Agricultural and Food Chemistry, 61(48), 11817-11824 (2013)
Transforming growth factor β (TGF-β) and inflammation in cancer
Bierie B, et al.
Cytokine & Growth Factor Reviews, 21(1), 49?59-49?59 (2010)
TGFβ3 / SfaN1 gene variant and the risk factor of nonsyndromic cleft palate only among Indonesian patients.
Nasroen SL, et al.
Cellular and Molecular Biology, 63(2), 88-91 (2017)
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