T0203

TGFβR2 (190-end), active, GST tagged human

PRECISIO^® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

• 동의어(들): AAT3, FAA3, HPNCC6, MFS2, RIIC, TAAD2, TGFR-2
• UNSPSC 코드: 12352200
• NACRES: NA.32

속성

• 생물학적 소스: human
• Quality Level: 100
• 재조합: expressed in baculovirus infected Sf9 cells
• 제품 라인: PRECISIO^® Kinase
• 분석: ≥70% (SDS-PAGE)
• 양식: buffered aqueous glycerol solution
• 특이 활성도: 6-8 nmol/min·mg
• 분자량: ~68 kDa
• UniProt 수납 번호: P37173
• 응용 분야: cell analysis
• 배송 상태: dry ice
• 저장 온도: −70°C
• 유전자 정보: human ... TGFBR2(7048)

설명

일반 설명

Transforming growth factor β receptor 2 (TGFBR2) is a member of the TGFß receptor subfamily and is a serine/threonine protein kinase. The gene encoding this protein is localized on human chromosome 3p24.1.[1][2]

생화학적/생리학적 작용

Transforming growth factor β receptor 2 (TGFBR2)-induced protein phosphorylation plays a key role in signal transduction that leads to mitogenic responses.[3] The TGFBR2 receptor transmits signals from the cell surface to the nucleus and provides instructions for making transforming growth factor (TGF)-β type II receptor. Mutations in TGFBR2 gene have been associated with Marfan syndrome, Loeys-Deitz aortic aneurysm syndrome and the development of various types of tumors.[4][5][6][7]

물리적 형태

Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.

법적 정보

PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)