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Merck
모든 사진(1)

주요 문서

SRP2096

Sigma-Aldrich

p300-Ch1 (302-531) human

recombinant, expressed in E. coli, ≥80% (SDS-PAGE)

동의어(들):

KAT3B, RP1-85F18.1, RSTS2, p300

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모든 사진(1)

About This Item

UNSPSC 코드:
12352200
NACRES:
NA.26

생물학적 소스

human

재조합

expressed in E. coli

분석

≥80% (SDS-PAGE)

양식

frozen liquid

분자량

~26 kDa

포장

pkg of 10 μg

농도

1000 μg/mL

색상

clear colorless

NCBI 수납 번호

NM_001429

UniProt 수납 번호

Q09472

배송 상태

dry ice

저장 온도

−70°C

유전자 정보

human ... EP300(2033)

일반 설명

The EP300 (E1A binding protein p300) gene is mapped to human chromosome 22q13.2.[1] It codes for a histone acetyltransferase which is ubiquitously expressed.[2]

생화학적/생리학적 작용

Human p300 and CBP (CREB binding protein) are highly related transcriptional coactivators. Both proteins have been identified through protein interaction assays. In addition to interacting with variety of cellular factors and onco-proteins, loss of the wild type CBP alleles in isolated tumors suggests that CBP/p300 might serve as tumor suppressors. The ability of p300 to acetylate many transcription factors, including p53, E2F, TFIIE, and TFIIF etc. demonstrated a novel mechanism of targeted p300 regulation of gene expression.
Loss of EP300 (E1A binding protein p300) gene function causes Rubinstein-Taybi syndrome.[3] p300 is essential for cell differentiation, growth and survival.[2] p300 promotes liver stiffness, which is known to induce hepatic stellate cell differentiation to tumor-promoting myofibroblasts.[4]

물리적 형태

Clear and colorless frozen liquid solution

제조 메모

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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시험 성적서(COA)

Lot/Batch Number
083094055

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문서 라이브러리 방문

Genome-wide sequencing expands the phenotypic spectrum of EP300 variants
Costain G, et al.
European Journal of Medical Genetics, 61(3), 125-129 (2018)
Dysregulation of Sirtuin 2 (SIRT2) and histone H3K18 acetylation pathways associates with adverse prostate cancer outcomes
Damodaran S, et al.
BMC Cancer, 17(1), 874-874 (2017)
P300 acetyltransferase mediates stiffness-induced activation of hepatic stellate cells into tumor-promoting myofibroblasts
Dou C, et al.
Gastroenterology, 154(8), 2209-2221 (2018)
Jeroen H Roelfsema et al.
American journal of human genetics, 76(4), 572-580 (2005-02-12)
CREB-binding protein and p300 function as transcriptional coactivators in the regulation of gene expression through various signal-transduction pathways. Both are potent histone acetyl transferases. A certain level of CREB-binding protein is essential for normal development, since inactivation of one allele
R Eckner et al.
Genes & development, 8(8), 869-884 (1994-04-15)
The growth-controlling functions of the adenovirus E1A oncoprotein depend on its ability ot interact with a set of cellular proteins. Among these are the retinoblastoma protein, p107, p130, and p300. We have isolated a cDNA encoding full-length human p300 and
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