추천 제품
생물학적 소스
human
재조합
expressed in E. coli
분석
≥80% (SDS-PAGE)
양식
frozen liquid
분자량
~19.5 kDa
포장
pkg of 10 μg
저장 조건
avoid repeated freeze/thaw cycles
농도
1000 μg/mL
색상
clear colorless
NCBI 수납 번호
UniProt 수납 번호
배송 상태
dry ice
저장 온도
−70°C
유전자 정보
human ... NCOA1(8648)
생화학적/생리학적 작용
Steroid receptor coactivator 1 (SRC1) is a transcriptional coactivator that mediates the activating functions of many of the nuclear hormone receptors. It is also known as NCoA1 and is a member of the SRC/p160 coactivator family. SRC1 has been shown to be over expressed in some cancers. SRC1 is a 160 kDa protein that contains several LXXLL motifs, which are involved in nuclear receptor interaction. The region 627-786 contains 3 LXXLL motifs that are involved in interaction with nuclear hormone receptorsand have been previously used in assays detecting ligand-dependent receptor-cofactor interactions. This protein contains the Tobacco Etch virus (TEV) protease site and can be cleaved using acTEV to yield untagged SRC1 RID. This protein will be useful for assays where a native untagged protein is desired.
물리적 형태
Clear and colorless frozen liquid solution
제조 메모
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.
Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
가장 최신 버전 중 하나를 선택하세요:
S A Oñate et al.
Science (New York, N.Y.), 270(5240), 1354-1357 (1995-11-24)
A yeast two-hybrid system was used to identify a protein that interacts with and enhances the human progesterone receptor (hPR) transcriptional activity without altering the basal activity of the promoter. Because the protein stimulated transactivation of all the steroid receptors
D M Heery et al.
Nature, 387(6634), 733-736 (1997-06-12)
The binding of lipophilic hormones, retinoids and vitamins to members of the nuclear-receptor superfamily modifies the DNA-binding and transcriptional properties of these receptors, resulting in the activation or repression of target genes. Ligand binding induces conformational changes in nuclear receptors
Toshihiko Yanase et al.
Internal medicine (Tokyo, Japan), 43(5), 368-373 (2004-06-23)
Coregulators are a group of proteins, which modulate the nuclear receptor transactivation function. In this study, a new "coregulator disease" concept was proposed from observations of a case of androgen insensitivity syndrome (AIS) and cases involving Rubinstein-Taybi syndrome and X-linked
활성 필터
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