SML3681
ATM-3507
≥95% (HPLC)
동의어(들):
ATM 3507, [3-[[2,3-Dimethyl-1-[3-(4-methyl-1-piperazinyl)propyl]-1H-indol-5-yl]oxy]phenyl][4-[2-(4-fluorophenyl)ethyl]-1-piperazinyl]-methanone
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모든 사진(2)
About This Item
실험식(Hill 표기법):
C37H46FN5O2
CAS Number:
Molecular Weight:
611.79
MDL number:
UNSPSC 코드:
12352200
NACRES:
NA.77
추천 제품
Quality Level
분석
≥95% (HPLC)
형태
powder
색상
, Colorless to light brown
solubility
DMSO: 2 mg/mL, clear
저장 온도
-10 to -25°C
생화학적/생리학적 작용
ATM-3507 is a potent anti-tropomyosin agent that disables Tpm3.1 containing actin filaments. It exhibits potent cytotoxic activity against multiple neuroblastoma cancer cell lines. ATM-3507 sensitizes cancer cells to anti-microtubule agents. ATM-3507 significantly prolonged mitotic arrest induced by anti-microtubule agent vinorelbine.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Identification of Cancer-Targeted Tropomyosin Inhibitors and Their Synergy with Microtubule Drugs
Molecular Cancer Therapeutics, 16(8), 1555-1565 (2017)
Molecular integration of the anti-tropomyosin compound ATM-3507 into the coiled coil overlap region of the cancer-associated Tpm3.1
Scientific Reports, 9(1), 11262-11262 (2019)
Xing Xu et al.
British journal of cancer, 125(2), 265-276 (2021-05-14)
Anti-microtubule agents are widely used to treat ovarian cancers, but the efficacy is often compromised by drug resistance. We investigated co-targeting the actin/tropomyosin cytoskeleton and microtubules to increase treatment efficacy in ovarian cancers and potentially overcome resistance. The presence of
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