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Merck
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SML3224

Sigma-Aldrich

Sugammadex sodium

≥95% (HPLC), powder, neuromuscular blocker reversing agent

동의어(들):

6-Perdeoxy-6-per(2-carboxyethyl)thio-γ-cyclodextrin, sodium Salt, Org 25969, Org-25969, Org25969

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크기 선택

25 MG
₩151,337
100 MG
₩487,505

₩151,337

구입 가능 여부는 고객센터에 문의하십시오.
벌크 견적 요청
모든 사진(1)

크기 선택

보기 변경
25 MG
₩151,337
100 MG
₩487,505

About This Item

실험식(Hill 표기법):
C72H104Na8O48S8
CAS Number:
343306-79-6
Molecular Weight:
2178.01
MDL number:
MFCD09954145
UNSPSC 코드:
12352107
NACRES:
NA.77

₩151,337

구입 가능 여부는 고객센터에 문의하십시오.
벌크 견적 요청

제품명

Sugammadex sodium, ≥95% (HPLC)

Quality Level

100

분석

≥95% (HPLC)

양식

powder

색상

white to beige

solubility

H2O: 2 mg/mL, clear

저장 온도

−20°C

SMILES string

O[C@@H]1[C@@H](O)[C@@H](O[C@@H]2[C@@H](CSCCC(O[Na])=O)O[C@H](O[C@@H]3[C@@H](CSCCC(O[Na])=O)O[C@H](O[C@H]4[C@H](O)[C@@H](O)[C@@H](O[C@@H]5[C@@H](CSCCC(O[Na])=O)O[C@H](O[C@@H]6[C@@H](CSCCC(O[Na])=O)O[C@H]7[C@H](O)[C@H]6O)[C@H](O)[C@H]5O)O[C@@H]4CSCCC(O[Na])

InChI

1S/C72H112O48S8.8Na/c73-33(74)1-9-121-17-25-57-41(89)49(97)65(105-25)114-58-26(18-122-10-2-34(75)76)107-67(51(99)43(58)91)116-60-28(20-124-12-4-36(79)80)109-69(53(101)45(60)93)118-62-30(22-126-14-6-38(83)84)111-71(55(103)47(62)95)120-64-32(24-128-16-8-40(87)88)112-72(56(104)48(64)96)119-63-31(23-127-15-7-39(85)86)110-70(54(102)46(63)94)117-61-29(21-125-13-5-37(81)82)108-68(52(100)44(61)92)115-59-27(19-123-11-3-35(77)78)106-66(113-57)50(98)42(59)90;;;;;;;;/h25-32,41-72,89-104H,1-24H2,(H,73,74)(H,75,76)(H,77,78)(H,79,80)(H,81,82)(H,83,84)(H,85,86)(H,87,88);;;;;;;;/q;8*+1/p-8/t25-,26-,27-,28-,29-,30-,31-,32-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,70-,71-,72-;;;;;;;;/m1......../s1

InChI key

KMGKABOMYQLLDJ-VKHHSAQNSA-F

생화학적/생리학적 작용

Selective relaxant binding agent (SRBA) for complexing aminosteroid nondepolarizing neuromuscular blockers (NMBs) in vitro and in vivo.
Sugammadex (Org 25969) is a selective relaxant binding agent (SRBA) for complexing aminosteroid nonpolarizing neuromuscular blockers (NMBs), including pipecuronium, rocuronium and vecuronium. Sugammadex effectively recovers muscle twitch blockade in vitro (EC50 = 1.2 μM, Emax = 95.1%; isolated mouse hemi-diaphragm under 90% block by 3.6 μM rocuronium) and reverses neuromuscular blockade in vivo (ED50 = 30 nmol/kg i.v. & Emax = 92.5% with guinea pigs under 90% neuromuscular block by 10 nmol/kg/min rocuronium i.v. infusion; >90% recovery at 1 mg/kg or 0.46 μmol/kg i.v. of M. tibialis contractions of cats under 95% block by 10.24 nmol/kg/min rocuronium i.v. infusion).

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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시험 성적서(COA)

Lot/Batch Number
0000363307
0000363306
0000358157
0000303375
0000303377

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문서 라이브러리 방문

H D de Boer et al.
British journal of anaesthesia, 96(4), 473-479 (2006-02-09)
Binding of the steroidal molecule of rocuronium by a cyclodextrin is a new concept for reversal of neuromuscular block. The present study evaluated the ability of Sugammadex Org 25969, a synthetic gamma-cyclodextrin derivative, to reverse constant neuromuscular block of about
Gul Dogan et al.
The Journal of surgical research, 248, 123-128 (2020-01-04)
After colorectal surgery, anastomotic leakage is a major cause of mortality and morbidity. There are many factors affecting anastomotic leakage. It is known that agents such as neostigmine that is used to reverse neuromuscular blockade have certain effects on anastomosis.
Ola Epemolu et al.
Anesthesiology, 99(3), 632-637 (2003-09-10)
The purpose of this study was to determine the changes in the plasma concentration of rocuronium and the reversal of its neuromuscular blockade after the intravenous infusion of Org 25969, the novel neuromuscular block-reversal agent, in anesthetized guinea pigs. Rocuronium
Seok Kyeong Oh et al.
Scientific reports, 9(1), 11268-11268 (2019-08-04)
Studies have reported that protracted dexamethasone treatment induces resistance to nondepolarizing neuromuscular blocking agents (NMBAs) and the association with nicotinic acetylcholine receptors in the diaphragm of rats. Here, we investigated the effect of protracted dexamethasone administration on the sensitivity to
Jae Moon Choi et al.
Journal of anesthesia, 33(6), 642-646 (2019-09-20)
Sugammadex is used to reverse neuromuscular block induced by rocuronium or vecuronium by forming a stable complex. If the binding capacity of any substance to sugammadex is large enough, this molecule will displace rocuronium or vecuronium from the complex. For
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