SML2996
SR-301
≥98% (HPLC)
동의어(들):
6-(1H-Imidazol-1-yl)-N-[2-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-3-pyridazinecarboxamide, N-(2-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)phenyl)-6-(1H-imidazol-1-yl)pyridazine-3-carboxamide, SR 301, SR301
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모든 사진(1)
크기 선택
보기 변경
5 MG
₩122,003
25 MG
₩492,072
About This Item
실험식(Hill 표기법):
C17H11F6N5O2
CAS Number:
Molecular Weight:
431.29
UNSPSC 코드:
51111800
NACRES:
NA.77
추천 제품
Quality Level
분석
≥98% (HPLC)
양식
powder
색상
white to beige
solubility
DMSO: 2 mg/mL, clear
저장 온도
−20°C
SMILES string
O=C(C1=NN=C(N2C=NC=C2)C=C1)NC3=C(C(O)(C(F)(F)F)C(F)(F)F)C=CC=C3
InChI key
COFASYKPDRGFKT-UHFFFAOYSA-N
생화학적/생리학적 작용
Orally bioavailable analog of the selective STING agonist SR-717 with good antitumor efficacy in a murine B16.F10 melanoma tumor model in vivo.
SR-301 is an orally bioavailable analog of the selective STING agonist SR-717. SR-301 shows higher potency than SR-717 by THP1-based ISRE reporter assay (EC50 = 0.6 vs. 2.1 μM, respectively) and shows good antitumor efficacy when administered orally in a murine B16.F10 melanoma tumor model in vivo (15 mg/kg/day p.o.).
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
가장 최신 버전 중 하나를 선택하세요:
시험 성적서(COA)
Lot/Batch Number
Emily N Chin et al.
Science (New York, N.Y.), 369(6506), 993-999 (2020-08-21)
Stimulator of interferon genes (STING) links innate immunity to biological processes ranging from antitumor immunity to microbiome homeostasis. Mechanistic understanding of the anticancer potential for STING receptor activation is currently limited by metabolic instability of the natural cyclic dinucleotide (CDN)
활성 필터
자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..
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