SML2657

MP-A08

≥98% (HPLC)

• 동의어(들): 4-Methyl-N-[2-[[[2-[[(4-methylphenyl)sulfonyl]amino]phenyl]imino]methyl]phenyl]benzenesulfonamide, NSC-122314
• 실험식(Hill 표기법): C₂₇H₂₅N₃O₄S₂
• CAS Number: 219832-49-2
• Molecular Weight: 519.64
• MDL number: MFCD01053753
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: white to beige
• solubility: DMSO: 2 mg/mL, clear
• 저장 온도: 2-8°C
• SMILES string: [S](=O)(=O)(Nc2c(cccc2)\N=C\c3c(cccc3)N[S](=O)(=O)c4ccc(cc4)C)c1ccc(cc1)C
• InChI key: FLDBNMYJUMAXDQ-TURZUDJPSA-N

설명

생화학적/생리학적 작용

ATP-competitive sphingosine kinase inhibitor that targets both SK1 and SK2 (SphK 1 and 2)

MP-A08 is a highly selective ATP-competitive sphingosine kinase inhibitor that targets both SK1 and SK2. It is more selective and acts by different mechanisms than other SK inhibitors. MP-A0 targets the ATP-binding pocket, rather than the sphingosine binding pocket, with Ki values of 6.9 and 27 μM, respectively. Also, both SKI-II and PF-543 are thought to act in part by targeting sphingosine kinase for proteasomal degradation, which is not the case with MP-A08. MP-A08 was found to suppress the growth of human lung tumor xenografts in mice, both inducing apoptosis and inhibiting angiogenesis.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable