SML2437

H-151

≥98% (HPLC)

• 동의어(들): 1-(4-Ethylphenyl)-3-(1H-indol-3-yl) urea
• 실험식(Hill 표기법): C₁₇H₁₇N₃O
• CAS Number: 941987-60-6
• Molecular Weight: 279.34
• MDL number: MFCD08026581
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: white to beige
• solubility: DMSO: 2 mg/mL, clear
• 저장 온도: 2-8°C
• SMILES string: [nH]1c2c(c(c1)NC(=O)Nc3ccc(cc3)CC)cccc2
• InChI: 1S/C17H17N3O/c1-2-12-7-9-13(10-8-12)19-17(21)20-16-11-18-15-6-4-3-5-14(15)16/h3-11,18H,2H2,1H3,(H2,19,20,21)
• InChI key: UJZDIKVQFMCLBE-UHFFFAOYSA-N

설명

생화학적/생리학적 작용

Antagonist of the stimulator of interferon genes (STING) protein

H-151 is an irreversible antagonist of the stimulator of interferon genes (STING) protein, a central signalling component of the cytosolic DNA sensing pathway. Although STING is a vital component of the innate immune pathways, it has also been shown to have a pathogenic role in some inflammatory diseases. H-151 is a potent and selective STING antagonist with inhibitory activity both in human cells and in vivo in mice. Given as a pretreatment, H-151 was shown to attenuate pathological features of autoinflammatory disease in mouse models, reducing systemic cytokine responses in mice treated with the STING agonist 10-carboxymethyl-9-acridanone (CMA)

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable