SML2184

Kevetrin hydrochloride

≥98% (HPLC)

• 동의어(들): Kevetrin hydrochloride, 4-Isothioureidobutyronitrile hydrochloride, Carbamimidothioic acid 3-cyanopropyl ester hydrochloride, NSC 525990 HCl
• 실험식(Hill 표기법): C₅H₉N₃S · HCl
• CAS Number: 66592-89-0
• Molecular Weight: 179.67
• MDL number: MFCD22572767
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• 분석: ≥98% (HPLC)
• 양식: powder
• 저장 조건: desiccated
• 색상: white to beige
• solubility: H₂O: 2 mg/mL, clear
• 저장 온도: −20°C
• SMILES string: NC(SCCCC#N)=N.Cl
• InChI: 1S/C5H9N3S.ClH/c6-3-1-2-4-9-5(7)8;/h1-2,4H2,(H3,7,8);1H
• InChI key: NCXJZJFDQMKRKM-UHFFFAOYSA-N

설명

생화학적/생리학적 작용

Kevetrin is an activator/stabilizer of wild type p53 tumor suppressor protein in human lung carcinoma and ovarian cancer cells that induces cell cycle arrest and apoptosis. Additionally Kevetrin down-regulates oncogenic mutant p53 in OVCAR-3 ovarian cancer cells. Kevetrin inhibits tumor growth in xenograft model of ovarian cancer.

wild type p53 stabilizer

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable