SML1873
(2R,6R)-Hydroxynorketamine hydrochloride
≥98% (HPLC)
동의어(들):
(2R,6R)-HNK hydrochloride; (2R,6R)-2-Amino-2-(2-chlorophenyl)-6-hydroxy-cyclohexanone hydrochloride
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모든 사진(1)
About This Item
실험식(Hill 표기법):
C12H14ClNO2 · HCl
CAS Number:
Molecular Weight:
276.16
MDL number:
UNSPSC 코드:
12352116
NACRES:
NA.77
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추천 제품
Quality Level
분석
≥98% (HPLC)
양식
powder
광학 활성
[α]/D -95 to -115°, c = 1 in H2O
약물 제어
regulated under CDSA - not available from Sigma-Aldrich Canada
저장 조건
desiccated
색상
white to beige
solubility
H2O: 25 mg/mL, clear
저장 온도
2-8°C
SMILES string
O=C1[C@@](C2=CC=CC=C2Cl)(N)CCC[C@H]1O.Cl
InChI
1S/C12H14ClNO2.ClH/c13-9-5-2-1-4-8(9)12(14)7-3-6-10(15)11(12)16;/h1-2,4-5,10,15H,3,6-7,14H2;1H/t10-,12-;/m1./s1
InChI key
ZQJVHBJDLMIKJK-MHDYBILJSA-N
생화학적/생리학적 작용
(2R,6R)-Hydroxynorketamine is a ketamine metabolite that has rapid antidepressant activity without ketamine-related side effects.
(2R,6R)-Hydroxynorketamine is a ketamine metabolite that has rapid antidepressant activity without ketamine-related side effects. The NMDAR antagonist (R,S)-ketamine must be metabolized to (2S,6S;2R,6R)-hydroxynorketamine (HNK) to have antidepressant effects. The (2R,6R)-HNK enantiomer appears to be the enantiomer most responsible for antidepressant effects in a mouse study and unlike (2S,6S)-HNK, (2R,6R)-HNK caused no significant changes in locomotion or coordination. (2R,6R)-HNK does not seem to have the same addiction potential as ketamine, since mice did not self-administer pharmacologically relevant doses of (2R,6R)-HNK under the same conditions where ketamine was readily self-administered. The (2R,6R)-HNK antidepressant appears to involve activation of AMPA glutamate receptors rather than inhibition of NMDA glutamate receptors.
신호어
Warning
유해 및 위험 성명서
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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시험 성적서(COA)
Lot/Batch Number
Panos Zanos et al.
Nature, 533(7604), 481-486 (2016-05-05)
Major depressive disorder affects around 16 per cent of the world population at some point in their lives. Despite the availability of numerous monoaminergic-based antidepressants, most patients require several weeks, if not months, to respond to these treatments, and many
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