N3136

Naltrexone hydrochloride

≥99% (HPLC), powder, opioid receptor antagonist

• 동의어(들): Naltrexone HCl
• 실험식(Hill 표기법): C₂₀H₂₃NO₄ · HCl
• CAS Number: 16676-29-2
• Molecular Weight: 377.86
• Beilstein: 3580333
• EC Number: 240-723-0
• MDL number: MFCD00069324
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24278051
• NACRES: NA.77

속성

• product name: Naltrexone hydrochloride,
• 형태: powder
• 주관자: Novartis
• 저장 온도: 2-8°C
• SMILES string: Cl.Oc1ccc2C[C@H]3N(CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35O)CC6CC6
• InChI: 1S/C20H23NO4.ClH/c22-13-4-3-12-9-15-20(24)6-5-14(23)18-19(20,16(12)17(13)25-18)7-8-21(15)10-11-1-2-11;/h3-4,11,15,18,22,24H,1-2,5-10H2;1H/t15-,18+,19+,20-;/m1./s1
• InChI key: RHBRMCOKKKZVRY-ITLPAZOVSA-N
• 유전자 정보: human ... OPRD1(4985) , OPRK1(4986) , OPRM1(4988) , OPRS1(10280)

설명

애플리케이션

Naltrexone hydrochloride has been used:

• as an opioid antagonist, to analyse its effect on ethanol preference using Caenorhabditis elegans as a model
• to determine its effectiveness in reducing the preference for substance of abuse (SOA) like nicotine and cocaine using Caenorhabditis elegans as a model
• in the preparation of combinatorial drug, PXT3003 for treating Charcot-Marie-Tooth disease 1A (CMT1A) transgenic rat model Pmp22

생화학적/생리학적 작용

Competitive antagonist for μ, κ, δ, and σ-opioid receptors; has greater oral efficacy and longer duration of action than naloxone.

특징 및 장점

This compound is featured on the Opioid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H302
• 예방조치 성명서: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves