추천 제품
Quality Level
분석
≥98% (HPLC)
양식
powder
색상
white to beige
solubility
DMSO: 20 mg/mL, clear
저장 온도
2-8°C
SMILES string
COCCCN1CCC(NC(C2=CC(Cl)=C(N)C3=C2OCC3)=O)CC1
InChI
1S/C18H26ClN3O3/c1-24-9-2-6-22-7-3-12(4-8-22)21-18(23)14-11-15(19)16(20)13-5-10-25-17(13)14/h11-12H,2-10,20H2,1H3,(H,21,23)
InChI key
ZPMNHBXQOOVQJL-UHFFFAOYSA-N
생화학적/생리학적 작용
In healthy male individuals, prucalopride decreases the display of esophageal acid and promotes gastric emptying.[1] It is effective, safe and shows good tolerance for the treatment of men with chronic constipation.[2]
Prucalopride is a selective 5-HT4 serotonin receptor agonist with enterokinetic activity.
Prucalopride is a selective 5-HT4 serotonin receptor agonist with enterokinetic activity. 5-HT4 receptors are GPCRs that are expressed in the CNS and peripheral tissues. The receptor has a role in GI motility disorders such as irritable bowel syndrome and idiopathic constipation. Agonists are prokinetic and of potential use for disoroders of reduced motility. Prucalopride is a selective 5-HT4 serotonin receptor agonist with enterokinetic activities. Prucalopride has pK(i) values of 8.60 and 8.10 for the human 5-HT(4a) and 5-HT(4b) receptor, respectively, and at least 290-fold selectivity for 5-HT4 over other serotonin and dopamine receptors.
신호어
Warning
유해 및 위험 성명서
Hazard Classifications
Aquatic Acute 1 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
표적 기관
Respiratory system
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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시험 성적서(COA)
Lot/Batch Number
이미 열람한 고객
A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Trial to Evaluate the Efficacy, Safety, and Tolerability of Prucalopride in Men With Chronic Constipation.
Yiannakou Y, et al.
The American Journal of Gastroenterology, 110(5), 741-741 (2015)
Prucalopride decreases esophageal acid exposure and accelerates gastric emptying in healthy subjects.
Kessing BF, et al.
Neurogastroenterology and Motility, 26(8), 1079-1086 (2014)
Wael Noor El-Nachef et al.
Development (Cambridge, England), 147(13) (2020-06-17)
The enteric nervous system (ENS) is essential for normal gastrointestinal function. Although the embryonic origin of enteric neurons from the neural crest is well established, conflicting evidence exists regarding postnatal enteric neurogenesis. Here, we address this by examining the origin
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