SML1251
Gomisin A
동의어(들):
(+)-Gomisin A, (6S,7S,13aR)- 5,6,7,8-Tetrahydro-1,2,3,13-tetramethoxy-6,7-dimethyl-benzo[3,4]cycloocta[1,2-f][1,3]benzodioxol-6-ol, Besigomsin, Schisandrol B, Schisantherinol B, Schizandrol B, TJN 101, Wuweizi alcohol B, Wuweizichun B
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5 MG
₩209,598
25 MG
₩801,444
About This Item
실험식(Hill 표기법):
C23H28O7
CAS Number:
Molecular Weight:
416.46
UNSPSC 코드:
12352200
PubChem Substance ID:
NACRES:
NA.77
추천 제품
생물학적 소스
Schisandra chinensis
Quality Level
양식
powder
색상
white to beige
solubility
DMSO: 20 mg/mL, clear
저장 온도
−20°C
SMILES string
C[C@]1([H])[C@@](C)(O)CC2=C(C(OC)=C(OC)C(OC)=C2)C3=C(OC)C4=C(OCO4)C=C3C1
InChI
1S/C23H28O7/c1-12-7-13-8-16-20(30-11-29-16)22(28-6)17(13)18-14(10-23(12,2)24)9-15(25-3)19(26-4)21(18)27-5/h8-9,12,24H,7,10-11H2,1-6H3/t12-,23-/m0/s1
InChI key
ZWRRJEICIPUPHZ-MYODQAERSA-N
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생화학적/생리학적 작용
Gomisin A guards against hepatic and renal injury stimulated by CCl(4) (carbon tetrachloride) exposure by differential modulation of the mitogen-activated protein kinases (MAPK) signal transduction pathway.[1] It also blocks inflammatory responses, promoted by lipopolysaccharide in N9 microglia by blocking the NF-κB (nuclear factor kappa light chain enhancer of activated B cells)/MAPKs pathway.[2]
Gomisin A is a major dibenzocyclooctadiene lignan from medicinal plant Schizandra Chinese that exhibit a wide variety of interesting biological activities, including hepatoprotective, antiviral, anticancer, neuroprotective and anti-inflammatory. Gomisin A suppressed the expressions of iNOS and COX-2 in LPS-stimulated N9 microglia through suppression of NF-κB/MAPKs pathway.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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시험 성적서(COA)
Lot/Batch Number
이미 열람한 고객
Protective effects of gomisin A isolated from Schisandra chinensis against CCl4-induced hepatic and renal injury
Hwang I S, et al.
International Journal of Molecular Medicine, 31(4), 888-898 (2013)
Xiaoxiao Wang et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 63, 119-127 (2013-11-12)
Gomisin A, one of the major dibenzocyclooctadiene lignans isolated from Schisandra chinensis Baill., has proved to possess a variety of pharmacological effects. The aim of the present study was to investigate the anti-inflammatory and neuroprotective effects of gomisin A as
Pornthip Waiwut et al.
Biological & pharmaceutical bulletin, 35(11), 1997-2003 (2012-11-06)
Gomisin A, a dibenzocyclooctadiene lignan isolated from the fruit of Schisandra chinensis, has been reported as an anti-cancer substance. In this study, we investigated the effects of gomisin A on cancer cell proliferation and cell cycle arrest in HeLa cells.
Jeong-Seok Kim et al.
Clinical and experimental pharmacology & physiology, 45(6), 547-555 (2018-01-11)
Gomisin A from the fruit of Schisandra chinensis has many pharmacological properties, including hepato-protective, anti-diabetic, and anti-oxidative stress. However, the potential benefit of gomisin A is still not well understood, especially in aging progression. Therefore, the aim of this study
Ji Young Park et al.
Hypertension research : official journal of the Japanese Society of Hypertension, 35(9), 928-934 (2012-04-27)
Gomisin A (GA) is a small molecular weight lignan present in Schisandra chinensis, and has been demonstrated to have vasodilatory activity. In the present study, we investigated the effect of GA on blood pressure (BP) in angiotensin II (Ang II)-induced
활성 필터
자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..
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