SML1186

GGTI-286 dihydrochloride

≥90% (HPLC)

• 동의어(들): (R)-N-[[5-[(2-Amino-3-mercaptopropyl)amino][1,1′-biphenyl]-2-yl]carbonyl]-L-lLeucine methyl ester dihydrochloride, GGTI 286 dihydrochloride, N-[[5-[[(2R)-2-Amino-3-mercaptopropyl]amino][1,1′-biphenyl]-2-yl]carbonyl]-L-leucine methyl ester dihydrochloride
• 실험식(Hill 표기법): C₂₃H₃₁N₃O₃S · 2HCl
• CAS Number: 171744-11-9
• Molecular Weight: 502.50
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• 분석: ≥90% (HPLC)
• 양식: powder
• 저장 조건: desiccated
• 색상: white to light brown
• solubility: DMSO: 20 mg/mL, clear
• 배송 상태: wet ice
• 저장 온도: −20°C
• SMILES string: SC[C@H](N)CNc1cc(c(cc1)C(=O)N[C@@H](CC(C)C)C(=O)OC)c2ccccc2
• InChI key: IENQPUVVSDIXCT-UTKZUKDTSA-N

설명

생화학적/생리학적 작용

GGTI-286 is a cell permeable, potent and selective inhibitor of geranylgeranyltransferase I (GGTase I) that selectively disrupts oncogenic K-Ras4B. New study shows that GGTI-286 reduces nuclear localization of β-catenin.

GGTI-286 is a cell permeable, potent and selective inhibitor of geranylgeranyltransferase I (GGTase I). CAAX peptidomimetic.

기타 정보

Air sensitive; dessicant.

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H315,H319,H335
• 예방조치 성명서: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 표적 기관: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable