SML0560

BRACO19 hydrochloride

≥96% (HPLC), powder, telomerase inhibitor

• 동의어(들): N,N′-(9-(4-(Dimethylamino)phenylamino)acridine-3,6-diyl)bis(3-(pyrrolidin-1-yl)propanamide) hydrochloride
• 실험식(Hill 표기법): C₃₅H₄₃N₇O₂ · xHCl
• CAS Number: 1177798-88-7
• Molecular Weight: 593.76 (free base basis)
• MDL number: MFCD23380200
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329825553
• NACRES: NA.77

속성

• product name: BRACO19 hydrochloride, ≥96% (HPLC)
• 분석: ≥96% (HPLC)
• 형태: powder
• 저장 조건: desiccated
• 색상: yellow to brown
• solubility: H₂O: 5 mg/mL, clear
• 저장 온도: 2-8°C
• SMILES string: Cl.Cl.Cl.CN(C)c1ccc(Nc2c3ccc(NC(=O)CCN4CCCC4)cc3nc5cc(NC(=O)CCN6CCCC6)ccc25)cc1
• InChI: 1S/C35H43N7O2.3ClH/c1-40(2)28-11-7-25(8-12-28)38-35-29-13-9-26(36-33(43)15-21-41-17-3-4-18-41)23-31(29)39-32-24-27(10-14-30(32)35)37-34(44)16-22-42-19-5-6-20-42;;;/h7-14,23-24H,3-6,15-22H2,1-2H3,(H,36,43)(H,37,44)(H,38,39);3*1H
• InChI key: MJAPNWJRLLDPAB-UHFFFAOYSA-N

설명

애플리케이션

BRACO19 hydrochloride has been used to study the role of antiviral activity of G4-stabilizing agents in cells infected with latent human immunodeficiency virus -1 (HIV-1).

생화학적/생리학적 작용

BRACO19 is a telomerase inhibitor that stabilizes G-quadruplexes, targeting telomeric G-quadruplexes, inducing DNA damage and cell-cycle arrest.

Telomerase is associated with tumor progression and is highly expressed in a number of tumors. BRACO19 is known to prevent the capping and catalytic action of telomerase and thus, might serve as an effective therapeutic approach for cancer treatment. BRACO19 establishes antiviral activity against HIV (human immunodeficiency virus).

안전성 정보

• 픽토그램: GHS06
• 신호어: Danger
• 유해 및 위험 성명서: H301
• 예방조치 성명서: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable