모든 사진(1)
About This Item
실험식(Hill 표기법):
C7H5ClO3
CAS Number:
Molecular Weight:
172.57
MDL number:
UNSPSC 코드:
12352200
PubChem Substance ID:
SML0447 제품과 관련한 질문은 현지 머크 영업소 또는 판매 사원에게 문의해 주십시오. 고객지원팀으로 연락바랍니다.
추천 제품
분석
≥97% (HPLC)
양식
powder
색상
white to beige
solubility
DMSO: 15 mg/mL (clear solution)
저장 온도
room temp
SMILES string
Oc1cc(Cl)cc(c1)C(O)=O
InChI
1S/C7H5ClO3/c8-5-1-4(7(10)11)2-6(9)3-5/h1-3,9H,(H,10,11)
InChI key
RJOLIYHZZKAIET-UHFFFAOYSA-N
생화학적/생리학적 작용
3-Chloro-5-hydroxybenzoic acid is a selective agonist of the lactate receptor, GPR81.
3-Chloro-5-hydroxybenzoic acid is a selective agonist of the lactate receptor, GPR81. Stimulation of either GPR81 or GPR109a in adipose tissue leads to a similar decrease in triglyceride lipolysis. Niacin is used to treat dyslipidemia via its agonism of GPR109a, but compliance is low due to side effects (flushing and pruritus), which are associated with GPR109a agonism. 3-Chloro-5-hydroxybenzoic acid is selective for GPR81 over other GPCRs, including GPR109a. While less potent than niacin (16 vs. 0.78 μM), it has similar activity as the same dose as niacin in animal studies and should not cause the flushing that is associated with niacin.
신호어
Danger
유해 및 위험 성명서
Hazard Classifications
Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
표적 기관
Respiratory system
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
가장 최신 버전 중 하나를 선택하세요:
Timothy P Brown et al.
Oncogene, 39(16), 3292-3304 (2020-02-20)
GPR81 is a G-protein-coupled receptor for lactate, which is upregulated in breast cancer and plays an autocrine role to promote tumor growth by tumor cell-derived lactate. Here we asked whether lactate has any paracrine role via activation of GPR81 in
Marvin Lambertus et al.
Acta physiologica (Oxford, England), 231(3), e13587-e13587 (2020-11-28)
Adult neurogenesis occurs in two major niches in the brain: the subgranular zone of the hippocampal formation and the ventricular-subventricular zone. Neurogenesis in both niches is reduced in ageing and neurological disease involving dementia. Exercise can rescue memory by enhancing
Rafaz Hoque et al.
Gastroenterology, 146(7), 1763-1774 (2014-03-25)
The NACHT, LRR, and pyrin domain-containing protein 3 (NLRP3) inflammasome induces inflammation in response to organ injury, but little is known about its regulation. Toll-like receptors (TLRs) provide the first signal required for activation of the inflammasome and stimulate aerobic
Haíssa de Castro Abrantes et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 39(23), 4422-4433 (2019-03-31)
The discovery of a G-protein-coupled receptor for lactate named hydroxycarboxylic acid receptor 1 (HCAR1) in neurons has pointed to additional nonmetabolic effects of lactate for regulating neuronal network activity. In this study, we characterized the intracellular pathways engaged by HCAR1
활성 필터
자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..
고객지원팀으로 연락바랍니다.
