![[Arg13] Amyloid-β-Protein Fragment 1-40 ≥80% (HPLC), lyophilized powder](/deepweb/assets/sigmaaldrich/product/images/132/249/f6ab5ff8-bec9-4c18-b8b8-7b6bc8f9d58e/640/f6ab5ff8-bec9-4c18-b8b8-7b6bc8f9d58e.jpg)
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This product is soluble in DMSO at 0.4 - 4 mM, as stated in the product datasheet. This equates to 1.8 - 18 mg/mL in DMSO. This stock solution may be diluted with aqueous buffers, such as PBS or saline, to the desired working concentration. Please see the link below to review the product datasheet:
https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/301/154/a9810pis.pdf
모든 사진(1)
크기 선택
보기 변경
0.1 MG
₩570,024
About This Item
실험식(Hill 표기법):
C203H311N55O60S
CAS Number:
Molecular Weight:
4514.04
MDL number:
UNSPSC 코드:
12352202
NACRES:
NA.32
추천 제품
분석
≥95% (HPLC)
Quality Level
양식
powder
UniProt 수납 번호
저장 온도
−20°C
SMILES string
S(CC[C@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(
InChI
1S/C203H311N55O60S/c1-28-106(20)164(195(310)220-91-149(267)228-130(71-98(4)5)181(296)238-129(66-70-319-27)179(294)251-158(100(8)9)193(308)218-87-146(264)215-88-151(269)250-160(102(12)13)198(313)255-163(105(18)19)199(314)258-165(107(21)29-2)200(315)227-112
InChI key
DZHSAHHDTRWUTF-SIQRNXPUSA-N
유전자 정보
human ... APP(351)
1 of 4
이 품목 | A2201 | A1075 | AG968 |
|---|---|---|---|
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 100 |
| form powder | form powder | form powder | form powder |
| UniProt accession no. | UniProt accession no. | UniProt accession no. | UniProt accession no. |
| Gene Information human ... APP(351) | Gene Information human ... APP(351) | Gene Information human ... APP(351) | Gene Information human ... APP(351) |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. - |
Amino Acid Sequence
Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala
일반 설명
애플리케이션
Amyloid β Protein Fragment 1-42 has been used:
- for the preparation of Aβ 1-42 oligomer[3][4]
- for western blot analysis[5]
- for the interference test of immunomagnetic reduction (IMR) plasma Aβ42 assay[6]
- to study the effects of resveratrol on Aβ 1-42-induced impairment of spatial learning, memory and synaptic plasticity[7]
- to investigate the effect of Aβ in epithelial cell culture[1]
생화학적/생리학적 작용
Amyloid β Protein Fragment 1-42 (Aβ 1-42) has antioxidant and neuroprotective properties.[8] Accumulation of amyloid β Protein is associated with Alzheimer′s disease (AD) and Down Syndrome.[9] Aβ 1-42 regulates cholesterol transport[10] and may function as a transcription factor.[11] It may possess anti-inflammatory and antimicrobial properties.[12]
The predominant fragment of amyloid β-protein found in the brains of patients with Alzheimer′s disease and Down′s syndrome.
관련 제품
제품 번호
설명
가격
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
가장 최신 버전 중 하나를 선택하세요:
시험 성적서(COA)
Lot/Batch Number
이미 열람한 고객
Resveratrol ameliorates spatial learning memory impairment induced by Abeta1-42 in rats
Wang R, et al.
Neuroscience, 344, 39-47 (2017)
Function of beta-amyloid in cholesterol transport: a lead to neurotoxicity
Yao ZX and Papadopoulos V
Faseb Journal, 16(12), 1677-1679 (2002)
Kyunghee Byun et al.
PloS one, 7(5), e37917-e37917 (2012-06-05)
Advanced glycation end products (AGEs) have long been considered as potent molecules promoting neuronal cell death and contributing to neurodegenerative disorders such as Alzheimer's disease (AD). In this study, we demonstrate that AGE-albumin, the most abundant AGE product in human
Plasma Amyloid-beta(Abeta 42) Correlates with Cerebrospinal Fluid Abeta 42 in Alzheimer?s Disease
Teunissen CE, et al.
Journal of Alzheimer'S Disease, 1-7 (2018)
beta-amyloid expression in age-related cataract lens epithelia and the effect of beta-amyloid on oxidative damage in human lens epithelial cells
Xu J, et al.
Molecular Vision, 23, 1015-1015 (2017)
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After dissolving in DMSO, I want to dilute it with saline (finally 1ml/1mg) and use it for i.c.v. injection in mice. How many µl of 0.4-4 mM DMSO per 0.1 mg should I dissolve in?
1 답변-
도움이 되었습니까?
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What is the difference between the AB peptide (1-42)(PP69) and AB protein fragment (1-42)(A9810)?
1 답변-
These products are functionally the same, but are different brands. The PP69 is a Calbiochem product, while the A9810 is from Sigma-Aldrich. The testing specifications are slightly different, however both offer a minimum purity of 95%. The A9810 is lyophilized from a solution of water and TFA. The PP69 is lyophilized from a solution of 50 mM Tris-HCl. Please see the links below to review the product datasheet for each:
PP69 Calbiochem:
https://www.emdmillipore.com/product/-Amyloid-Peptide-1-42-Human,EMD_BIO-PP69#anchor_PDS
A9810 Sigma-Aldrich:
https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/301/154/a9810pis.pdf도움이 되었습니까?
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It is instructed to dissolve the product in Ammonium Hydroxide solution, but what should be the molarity / Concentration of the ammonium hydroxide solution
1 답변-
This product can be solubilized in ammonium hydroxide at a pH greater than 9. The concentration is not reported. It is recommended to prepare at a minimum 1 mg/mL concentration.
도움이 되었습니까?
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How much ammonium hydroxide (pH >9) should be added to the 0,1 mg vial ? Is it possible to vortex the vial ?
1 답변-
It is recommended to prepare a solution at a minimum of 1 mg/mL of ammonium hydroxide. Vertexing the vial is not necessary.
도움이 되었습니까?
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in which solvent it should be dissolved ?
1 답변-
As per the product information sheet, this product is soluble in ammonium hydroxide, pH >9, or in DMSO at 0.4–4 mM. Solutions can then be diluted into aqueous buffers such as10 mM sodium phosphate for use. Other reported solvents include hexafluoroisopropanol, acetonitrile, and acetic acid.
See the link below to review the product information sheet:
https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/301/154/a9810pis.pdf도움이 되었습니까?
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What is the secondary structure of Product A9810, Amyloid β Protein Fragment 1-42?
1 답변-
The secondary structure of this fragment will exist as a mixture of B-sheet, a-helix, and random coil structures dependent upon the solution conditions as described in J. Mol. Biol., 225, 1075-1083, 1992
도움이 되었습니까?
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What is the Department of Transportation shipping information for this product?
1 답변-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
도움이 되었습니까?
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What is the source of Product A9810, Amyloid β Protein Fragment 1-42?
1 답변-
This protein fragment is a synthetic organic. The gene for this peptide is located on human chromosome 21.
도움이 되었습니까?
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What is the pI of Product A9810, Amyloid β Protein Fragment 1-42?
1 답변-
The pI as calculated from the amino acid sequence for Product A9810, Amyloid β Protein Fragment 1-42, is 5.31.
도움이 되었습니까?
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Is the mouse protein fragment the same as the human protein fragment in Product A9810, Amyloid β Protein Fragment 1-42?
1 답변-
The homology is 93% by identity, 95% positives... no gaps
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