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Merck
모든 사진(1)

주요 문서

SML0438

Sigma-Aldrich

Mibolerone

≥98% (HPLC)

동의어(들):

(7α,17β)-17-Hydroxy-7,17-dimethylestr-4-en-3-one, 7α,17α-Dimethyl-19-nortestosterone

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모든 사진(1)

About This Item

실험식(Hill 표기법):
C20H30O2
CAS Number:
3704-09-4
Molecular Weight:
302.45
EC Number:
223-046-5
UNSPSC 코드:
51111800
NACRES:
NA.77
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분석

≥98% (HPLC)

양식

powder

약물 제어

USDEA Schedule IIIN; regulated under CDSA - not available from Sigma-Aldrich Canada

색상

white to beige

solubility

DMSO: 5 mg/mL, clear (warmed)

저장 온도

2-8°C

SMILES string

O[C@@]1([C@@]2([C@H]([C@H]3[C@@H]([C@H]4CCC(=O)C=C4C[C@H]3C)CC2)CC1)C)C

InChI

1S/C20H30O2/c1-12-10-13-11-14(21)4-5-15(13)16-6-8-19(2)17(18(12)16)7-9-20(19,3)22/h11-12,15-18,22H,4-10H2,1-3H3/t12-,15+,16-,17+,18-,19+,20+/m1/s1

InChI key

PTQMMNYJKCSPET-OMHQDGTGSA-N

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일반 설명

The synthetic androgen mibolerone (7α,17α dimethyl-19-nortestosterone) is an androgenic steroid.[1]

생화학적/생리학적 작용

Mibolerone is a synthetic anabolic steroid with a similar profile of activity as R1881 (Metribolone) with a higher affinity (Kd = 1.5 nM) for the androgen receptor in human prostate tissue than R1881 (Kd = 2.3 nM).
Mibolerone is a synthetic anabolic steroid; potent androgen receptor agonist.
The synthetic androgen mibolerone (7α,17α dimethyl-19-nortestosterone) reversibly blocks the multiplication of LNCaP (human prostate carcinoma cell line) cells.[2] In prostate, liver, and cultured cells, it serves as an efficient radioactive ligand for the quantitation and characterization of androgen receptors.[3]

픽토그램

Health hazard
GHS08

신호어

Danger

유해 및 위험 성명서

H360

Hazard Classifications

Repr. 1B

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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시험 성적서(COA)

Lot/Batch Number
126M4730V
023M4727V

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문서 라이브러리 방문

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Contraceptives are used for reversible reproductive control in genetically valuable wild felids, as permanent reproductive control in generic wild felids, and as an economically practicable means to control feral cats. The progestin contraceptives, megestrol acetate, melengesterol acetate, medroxyprogesterone acetate, and
R J Edmondson et al.
British journal of cancer, 86(6), 879-885 (2002-04-16)
The pathogenesis of epithelial ovarian cancer remains unclear. From epidemiological studies raised levels of androgens have been implicated to increase the risk of developing the disease. The purpose of this study was to determine the responses of normal human ovarian
Transcriptional down-regulation of c-myc in human prostate carcinoma cells by the synthetic androgen mibolerone.
Wolf DA, et al.
British Journal of Cancer, 65(3), 376?382-376?382 (1992)
Dian-qi Xin et al.
Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences, 37(6), 638-640 (2005-12-27)
To identify the androgen-responsive genes in prostate and screen the molecular targets for further studying human prostate cancer. The potential androgen-responsive gene pituitary tumor transforming gene 1 (PTTG1) was selected which had been previously screened by cDNA microarray in rat
Erik J Tokar et al.
Differentiation; research in biological diversity, 73(9-10), 463-473 (2005-12-15)
Theories of cell lineage in human prostatic epithelium, based on protein expression, propose that basal and luminal cells: 1) are either independently capable of self-renewal or 2) arise from stem cells expressing a full spectrum of proteins (p63, cytokeratins CK5/14
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