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Merck
모든 사진(1)

주요 문서

SCP0196

Sigma-Aldrich

Myosin Light Chain Kinase Substrate

≥95% (HPLC), lyophilized

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크기 선택

1 MG
₩198,636

₩198,636

구입 가능 여부는 고객센터에 문의하십시오.
모든 사진(1)

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보기 변경
1 MG
₩198,636

About This Item

실험식(Hill 표기법):
C61H107N23O16
Molecular Weight:
1418.65
UNSPSC 코드:
12352202
NACRES:
NA.32

₩198,636

구입 가능 여부는 고객센터에 문의하십시오.

제품명

Myosin Light Chain Kinase Substrate (smooth muscle),

분석

≥95% (HPLC)

양식

lyophilized

구성

Peptide Content, ≥62%

저장 조건

protect from light

저장 온도

−20°C

Amino Acid Sequence

Lys-Lys-Arg-Ala-Ala-Arg-Ala-Thr-Ser-Asn-Val-Phe-Ala-NH2

일반 설명

Myosin light chain kinase (MLCK) comprises an N-terminal actin-binding domain, a central kinase domain, and a C-terminal myosin-binding domain.[1]

애플리케이션

Myosin Light Chain Kinase Substrate (smooth muscle) has been used in MLCK activity assay to study the role of Plasmodium falciparum calmodulin (Pf CaM).[2]

생화학적/생리학적 작용

KKRAARATSNVFA-NH2 is used as a myosin light chain kinase (MLCK) substrate.
Myosin light chain kinase (MLCK) is involved in modulating the actin-myosin interaction of smooth muscle. In addition to its kinase activity, MLCK also has actin-binding activity, which can assemble actin filaments into bundles. It also has myosin-binding activity, which can generate myosin filaments.[1]

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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시험 성적서(COA)

Lot/Batch Number
CL0230

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문서 라이브러리 방문

Yevgeny Zolotarevsky et al.
Gastroenterology, 123(1), 163-172 (2002-07-10)
Maintenance of the mucosal barrier is a critical function of intestinal epithelia. Myosin regulatory light chain (MLC) phosphorylation is a common intermediate in the pathophysiologic regulation of this barrier. The aim of this study was to determine whether a membrane
A V Sekridova et al.
Bioorganicheskaia khimiia, 36(4), 498-504 (2010-09-09)
Myosin light chain kinase (MLCK) is the key regulator of various forms of cell motility including endothelial and epithelial permeability in particular. One of the potential MLCK inhibitors to be used in humans is a membrane permeable peptide H-RKKYKYRRK-NH2 (L-PIK).
A V Marchenko et al.
Biofizika, 55(6), 1008-1013 (2011-01-28)
The ability of novel cell-permeating peptide molecules derived from the peptide inhibitor of the myosin light chain kinase (MLCK) L-PIK (Arg-Lys-Lys-Tyr-Lys-Tyr-Arg-Arg-Lys) to inhibit this kinase in vitro and attenuate the thrombin-induced hyperpermeability of endothelial cell monolayer in culture has been
Haruhiko Ohtsu et al.
Arteriosclerosis, thrombosis, and vascular biology, 25(9), 1831-1836 (2005-07-05)
Rho and its effector Rho-kinase/ROCK mediate cytoskeletal reorganization as well as smooth muscle contraction. Recent studies indicate that Rho and ROCK are critically involved in vascular remodeling. Here, we tested the hypothesis that Rho/ROCK are critically involved in angiotensin II
Structure and function of smooth muscle myosin light chain kinase.
Kishi, et al.
Advances in Experimental Medicine and Biology, 453, 229-234 (2019)
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