SAB4700374

Monoclonal Anti-CD41a antibody produced in mouse

clone HIP8, purified immunoglobulin, buffered aqueous solution

• 동의어(들): Anti-ITGA2B
• UNSPSC 코드: 12352203
• NACRES: NA.41

속성

• 생물학적 소스: mouse
• 결합: unconjugated
• 항체 형태: purified immunoglobulin
• 항체 생산 유형: primary antibodies
• 클론: HIP8, monoclonal
• 양식: buffered aqueous solution
• 종 반응성: nonhuman primates, human
• 농도: 1 mg/mL
• 기술: flow cytometry: suitable
• 동형: IgG1
• NCBI 수납 번호: NM_000419.3
• UniProt 수납 번호: P08514
• 배송 상태: wet ice
• 저장 온도: 2-8°C
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... ITGA2B(3674)

설명

일반 설명

Cluster of differentiation 41 (CD41), also known as integrin subunit α 2b (ITGA2B) or GPIIb/IIIa (glycoprotein), is encoded by the gene mapped to human chromosome 17q21.31. It is a platelet-specific, surface membrane receptor.

The antibody HIP8 reacts with alpha (α) subunit of CD41 (heavy chain; 120 kDa). CD41 is mainly expressed on platelets and megakaryocytes. The antibody HIP8 blocks platelet aggregation and completely inhibits ADP-, epinephrine-, and collagen-induced platelet activation, and partially inhibits ristocetin- and thrombin-induced platelet activation. HIP8 is useful in the morphological and physiological studies of platelets and megakaryocytes.

애플리케이션

The reagent is designed for Flow Cytometry analysis of human blood cells using 0.5 μg reagent / 1e6 cells in a suspension

생화학적/생리학적 작용

Cluster of differentiation 41(CD41) is significantly involved in platelet adhesion and thrombus formation at the location of vascular injury. Fibrinogen and many extracellular matrix proteins bind in a groove between the αand β-subunits of the integrin receptor. Platelet aggregation, induced by the binding of fibrinogen to the ITGA2B receptor, is involved in the pathogenesis of acute thrombosis in coronary heart disease, stroke and peripheral arterial disease. CD41, expressed in haematopoietic progenitors, is associated with erythroid activity and endothelial marker expression. Single-nucleotide polymorphisms (SNPs) in CD41 might be associated with the risk of acute coronary syndrome and atherosclerosis.

특징 및 장점

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

물리적 형태

Solution in phosphate buffered saline, pH 7.4, with 15 mM sodium azide.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable