SRC (proto-oncogene, non-receptor tyrosine kinase) belongs to the Src family kinases (SFKs). It contains an amino-terminal domain, conserved Src-homology domains (SH2 and SH3), a tyrosine kinase domain and the carboxyl-terminus. This gene is located on human chromosome 20q11.
๋ฉด์ญ์
The antiserum was produced against synthesized peptide derived from human Src around the phosphorylation site of Tyr418.
Immunogen Range: 386-435
์ ํ๋ฆฌ์ผ์ด์
Anti-phospho-Src (pTyr418) antibody has been used in immunofluorescence.
์ํํ์ /์๋ฆฌํ์ ์์ฉ
SRC (proto-oncogene, non-receptor tyrosine kinase) controls early HIV-1 (human immunodeficiency virus 1) infection post-entry. This gene participates in fundamental physiological and pathological processes like carcinogenesis and tumor progression. Src kinase activity helps in the migration of endothelial cells.
ํน์ง ๋ฐ ์ฅ์
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
๋ฌผ๋ฆฌ์ ํํ
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
๋ฉด์ฑ ์กฐํญ
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
madSTORM: a superresolution technique for large-scale multiplexing at single-molecule accuracy.
Yi J, et al.
Molecular Biology of the Cell, 27(22), 3591-3600 (2016)
SH3 domain of c-Src governs its dynamics at focal adhesions and the cell membrane.
Machiyama H
FEBS Journal, 282(20), 4034-4055 (2015)
c-Src activation promotes nasopharyngeal carcinoma metastasis by inducing the epithelial-mesenchymal transition via PI3K/Akt signaling pathway: a new and promising target for NPC
Ke L, et al.
Oncotarget, 7(19), 28340-28355 (2016)
Subcellular and Dynamic Coordination between Src Activity and Cell Protrusion in Microenvironment.
Zhuo Y
Scientific Reports, 5, 12963-12963 (2015)
c-SRC protein tyrosine kinase regulates early HIV-1 infection post-entry
