Anti-GAD1 antibody detects endogenous levels of total GAD1 protein.
GAD1 gene (glutamate decarboxylase 1) codes for a glutamic acid decarboxylase enzyme (GAD67), that is of 67 kDa. It is mapped to human chromosome 2q31.1.
면역원
The antiserum was produced against synthesized peptide derived from human GAD1.
Immunogen Range: 471-520
생화학적/생리학적 작용
GAD1 gene (glutamate decarboxylase 1) participates in GABA (γ-aminobutyric acid) synthesis. Variations in GAD1 results in hyperactivity in attention-deficit/hyperactivity disorder. It is also characterized with childhood-onset schizophrenia and cortical gray matter volume loss.
특징 및 장점
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물리적 형태
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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GAD1 gene polymorphisms are associated with hyperactivity in Attention-Deficit/Hyperactivity Disorder
Bruxel EM, et al.
American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics, 171(8), 1099-1104 (2016)
GAD1 (2q31.1), which encodes glutamic acid decarboxylase (GAD67), is associated with childhood-onset schizophrenia and cortical gray matter volume loss.
Addington AM, et al.
Molecular Psychiatry, 10(6), 581-588 (2005)
GAD1 Gene Expression in Blood of Patients with First-Episode Psychosis
Yee JY, et al.
PLoS ONE, 12(1), e0170805-e0170805 (2017)
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