SAB4500662
Anti-Aggrecan (Cleaved-Asp369), N-Terminal antibody produced in rabbit
affinity isolated antibody
동의어(들):
CSPCP, CSPG1, aggrecan core protein, cartilage-specific proteoglycan core protein, chondroitin sulfate proteoglycan core protein 1
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크기 선택
100 μG
₩834,229
₩834,229
구입 가능 여부는 고객센터에 문의하십시오.
모든 사진(2)
크기 선택
보기 변경
100 μG
₩834,229
About This Item
UNSPSC 코드:
12352203
NACRES:
NA.41
₩834,229
구입 가능 여부는 고객센터에 문의하십시오.
추천 제품
생물학적 소스
rabbit
Quality Level
결합
unconjugated
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
양식
buffered aqueous solution
분자량
antigen 44 kDa
종 반응성
human, rat
농도
~1 mg/mL
기술
ELISA: 1:20000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI 수납 번호
UniProt 수납 번호
배송 상태
wet ice
저장 온도
−20°C
타겟 번역 후 변형
proteolytically cleaved (Asp369)
유전자 정보
human ... ACAN(176)
일반 설명
Anti-Aggrecan (Cleaved-Asp369) Antibody detects endogenous levels of fragment of activated Aggrecan (Cleaved-Asp369) protein.
Aggrecan is a large aggregating chondroitin sulfate proteoglycan of the human cartilage. It is encoded by AGC1 (aggrecan) gene. It is located on human chromosome 15q26.1.
면역원
The antiserum was produced against synthesized peptide derived from human Aggrecan.
Immunogen Range: 320-369
Immunogen Range: 320-369
애플리케이션
생화학적/생리학적 작용
Mutations in aggrecan results in autosomal dominant short stature with accelerated skeletal maturation. Mutation in the variable repeat region of the aggrecan gene (AGC1) leads to spondyloepiphyseal dysplasia.
특징 및 장점
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
물리적 형태
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
nwg
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
가장 최신 버전 중 하나를 선택하세요:
Gene expression profiles of early chondrogenic markers in dedifferentiated fat cells stimulated by bone morphogenetic protein 4 under monolayer and spheroid culture conditions in vitro
Eiko A, et al.
Orthodontic Waves, 75(4), 97-104 (2016)
Clinical Characterization of Patients With Autosomal Dominant Short Stature due to Aggrecan Mutations.
Gkourogianni A, et al.
The Journal of Clinical Endocrinology and Metabolism, 102(2), 460-469 (2017)
Feng-Lai Yuan et al.
Cell stress & chaperones, 21(1), 97-104 (2015-09-20)
Acidic conditions are present in degenerated intervertebral discs and are believed to be responsible for matrix breakdown. Acid-sensing ion channel 1a (ASIC1a) is expressed in endplate chondrocytes, and its activation is associated with endplate chondrocyte apoptosis. However, the precise role
Complete coding sequence and deduced primary structure of the human cartilage large aggregating proteoglycan, aggrecan. Human-specific repeats, and additional alternatively spliced forms.
Doege K J, et al.
The Journal of Biological Chemistry, 266(2), 894-902 (1991)
A Mutation in the Variable Repeat Region of the Aggrecan Gene (AGC1) Causes a Form of Spondyloepiphyseal Dysplasia Associated with Severe, Premature Osteoarthritis
Lindsay G, et al.
American Journal of Human Genetics, 77(3), 484-490 (2005)
활성 필터
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