SAB4301136

Anti-c-Myc Tag antibody produced in rabbit

affinity isolated antibody

• 동의어(들): Myc Tag Antibody, Myc Tag Antibody - Anti-c-Myc Tag antibody produced in rabbit, c- Myc epitope Tag
• UNSPSC 코드: 12352203
• NACRES: NA.43

속성

• 생물학적 소스: rabbit
• Quality Level: 100
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 양식: buffered aqueous solution
• 분자량: 55 kDa
• 농도: 1 mg/mL
• 기술: western blot: 1:1000-1:5000 (Cell Lysate)
• 동형: IgG
• 배송 상태: wet ice
• 저장 온도: −20°C
• 타겟 번역 후 변형: unmodified

설명

일반 설명

c-Myc (v-myc avian myelocytomatosis viral oncogene homolog) is a transcription factor, which is coded by MYC gene. It was first described as a homolog of an avian retroviral oncogene. It belongs to the family of transcription factors which are characterized by basic region helix-loop-helix/leucine zipper. Along with N-Myc and L-Myc, it forms the MYC proto-oncogene family. It forms a heterodimer with MAX, and this heterodimer binds to the E-boxes/CACGTG sequence motif on DNA. This gene is localized to human chromosome 8q24.

특이성

The antibody detects transfected proteins contanining c-Myc Tag.

면역원

Synthetic peptide: C-EQKLISEEDL conjugated with KLH.

애플리케이션

Anti-c-Myc Tag antibody produced in rabbit has been used in western blotting.[1]

생화학적/생리학적 작용

v-myc avian myelocytomatosis viral oncogene homolog belongs to MYC family. When overexpressed, these proteins can delay the resolution of DNA lesions and cause DNA double-strand breaks (DSBs) and genome instability. This transcription factor MYC helps in regulating long noncoding RNAs (lncRNAs), which has been implicated in cancer cell proliferation and tumorigenesis. Its overexpression is also associated with various cancers, and in particular B cell lymphomas. Elevated expression of c-MYC inhibits the ability of B cell lymphomas to functionally present antigens/peptides to CD4⁺ T cells. It is associated with Burkitt lymphoma and a group of diffuse large B-cell lymphoma (DLBCL).

특징 및 장점

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물리적 형태

Rabbit IgG in pH7.3 PBS, 0.05% NaN₃, 50% Glycerol.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1