SAB4300576

Anti-ATR (Ab-428) antibody produced in rabbit

affinity isolated antibody

• 동의어(들): Anti-FRP1 antibody produced in rabbit, Anti-MEC1 antibody produced in rabbit, Anti-SCKL antibody produced in rabbit, Anti-SCKL1 antibody produced in rabbit, Anti-ataxia telangiectasia and Rad3 related antibody produced in rabbit
• UNSPSC 코드: 12352203
• NACRES: NA.41
• 결합: unconjugated
• application: IHC (p)
• 클론: polyclonal
• 종 반응성: human
• citations: 1
• 기술: immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100

속성

• 생물학적 소스: rabbit
• Quality Level: 100
• 결합: unconjugated
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 양식: buffered aqueous solution
• 분자량: ~250 kDa
• 종 반응성: human
• 농도: 1 mg/mL
• 기술: immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100
• 동형: IgG
• 면역원 서열: (G-I-S-P-K)
• NCBI 수납 번호: NP_001175.2
• UniProt 수납 번호: Q13535
• 배송 상태: wet ice
• 저장 온도: −20°C
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... ATR(545)

설명

면역원

Peptide sequence around aa. 426-430 (G-I-S-P-K), according to the protein ATR.

특징 및 장점

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표적 설명

ATR encoded by this gene belongs the PI3/PI4-kinase family, and is most closely related to ATM, a protein kinase encoded by the gene mutated in ataxia telangiectasia. This protein and ATM share similarity with Schizosaccharomyces pombe rad3, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This kinase has been shown to phosphorylate checkpoint kinase CHK1, checkpoint proteins RAD17, and RAD9, as well as tumor suppressor protein BRCA1. Mutations of this gene are associated with Seckel syndrome. An alternatively spliced transcript variant of this gene has been reported, however, its full length nature is not known. Transcript variants utilizing alternative polyA sites exist.

물리적 형태

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable