SAB4300115

Anti-phospho-CFL1 (pSer³) antibody produced in rabbit

affinity isolated antibody

• 동의어(들): Anti-CFL antibody produced in rabbit, Anti-cofilin 1 (non-muscle) antibody produced in rabbit
• UNSPSC 코드: 12352203
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• 결합: unconjugated
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 양식: buffered aqueous solution
• 분자량: ~19 kDa
• 종 반응성: rat, human, mouse
• 농도: 1 mg/mL
• 기술: immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100; indirect immunofluorescence: 1:100-1:200; western blot: 1:500-1:1000
• 동형: IgG
• 면역원 서열: (M-A-SP-G-V)
• NCBI 수납 번호: NP_005498.1
• UniProt 수납 번호: P23528
• 배송 상태: wet ice
• 저장 온도: −20°C
• 타겟 번역 후 변형: phosphorylation (pSer3)
• 유전자 정보: human ... CFL1(1072)

설명

일반 설명

The cofilin 1 (CFL1) gene is mapped to human chromosome 11q13.1. It has four exons. The CFL1 gene codes for a ubiquitously expressed, 18.5 kDa phosphoprotein.

면역원

Peptide sequence around phosphorylation site of serine 3 (M-A-S(p)-G-V), according to the protein CFL1.

애플리케이션

Anti-phospho-CFL1 (pSer3) antibody produced in rabbit is used in Western Blotting.

생화학적/생리학적 작용

Cofilin-l (CFL1) plays a vital role in the regulation of actin cytoskeleton reorganization. It facilitates cytokinesis, cell motility and morphogenesis. CFL1 is also implicated in cancer cell migration and invasion in several types of tumor tissues. Elevated expression of the protein is associated with the development of esophageal squamous cell carcinoma (ESCC). In addition, its abnormal expression leads to vulvar cancer and thus, it can be considered as a potential therapeutic target for the same. Activated CFL1 helps in preventing cytoskeletal-associated defects in axonal development stimulated by synucleins (Syns).

특징 및 장점

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표적 설명

Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods.

물리적 형태

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable