SAB4300109

Anti-phospho-RB1 (pSer⁷⁸⁰) antibody produced in rabbit

affinity isolated antibody

• 동의어(들): Anti-OSRC antibody produced in rabbit, Anti-RB antibody produced in rabbit, Anti-p105-Rb antibody produced in rabbit, Anti-pRb antibody produced in rabbit, Anti-retinoblastoma 1 antibody produced in rabbit
• MDL number: MFCD00282455
• UNSPSC 코드: 12352203
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• Quality Level: 100
• 결합: unconjugated
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 양식: buffered aqueous solution
• 분자량: ~110 kDa
• 종 반응성: human, mouse, rat
• 농도: 1 mg/mL
• 기술: immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100; indirect immunofluorescence: 1:100-1:200; western blot: 1:500-1:1000
• 동형: IgG
• 면역원 서열: (T-L-SP-P-I)
• NCBI 수납 번호: NP_000312.2
• UniProt 수납 번호: P06400
• 배송 상태: wet ice
• 저장 온도: −20°C
• 타겟 번역 후 변형: phosphorylation (pSer780)
• 유전자 정보: human ... RB1(5925)

설명

면역원

Peptide sequence around phosphorylation site of serine 780 (T-L-S(p)-P-I), according to the protein RB1.

특징 및 장점

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표적 설명

Key regulator of entry into cell division that acts as a tumor suppressor. Acts as a transcription repressor of E2F1 target genes. The underphosphorylated, active form of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Inhibits the intrinsic kinase activity of TAF1. In case of viral infections, interactions with SV40 large T antigen, HPV E7 protein or adenovirus E1A protein induce the disassembly of RB1-E2F1 complex thereby disrupting RB1's activity.

물리적 형태

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable