SAB4200228

Anti-Glycogen Synthase 2 antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody

• 동의어(들): Anti-GYS2, Anti-Glycogen synthase 2 (liver), Anti-LGS
• UNSPSC 코드: 12352203
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• 결합: unconjugated
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 양식: buffered aqueous solution
• 분자량: antigen ~85 kDa
• 종 반응성: rat, mouse
• 농도: ~1.0 mg/mL
• 기술: immunohistochemistry: 10-20 μg/mL using formalin-fixed paraffin-embedded rat liver; western blot: 1.5-3 μg/mL using mouse liver extracts (S1 fraction)
• UniProt 수납 번호: P17625
• 배송 상태: dry ice
• 저장 온도: −20°C
• 타겟 번역 후 변형: unmodified
• 유전자 정보: mouse ... Gys2(232493)

설명

일반 설명

Glycogen synthase 2 (GYS2) codes for a rate-limiting enzyme, glycogen synthase. The encoded protein is exclusively expressed in liver.

면역원

synthetic peptide located at the C-terminus of mouse glycogen synthase 2 (GYS2), conjugated to KLH. The corresponding sequence is highly conserved in rat GYS2 (single amino acid substitution) and in human GYS2 (84% identity).

애플리케이션

Anti-Glycogen Synthase 2 antibody produced in rabbit has been used in immunoblotting and immunohistochemistry.

생화학적/생리학적 작용

Glycogen synthase 2 (GS-2) plays a vital role as a rate limiting enzyme in glycogenesis pathway in liver and adipose tissue. It acts a target gene of peroxisome proliferator-activated receptors (PPARα, PPARβ/δ and PPARγ), which are transcription factors implicated in regulation of lipid and glucose metabolism. Mutation in the gene is associated with the pathogenesis of inherited monogenic disease glycogen storage disease 0 (GSD0).

물리적 형태

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable