Acyl-CoA thioesterase 13 (ACOT13), also known as thioesterase superfamily member 2 (THEM-2), is encoded by the gene mapped to human chromosome 6p22.3. The encoded protein has a molecular mass of ∼15kDa with 140 amino acids. It is a member of the hotdog-domain thioesterase family. THEM2 is highly expressed in several tissues such as heart, kidney, liver and brown adipose tissue (BAT). It has been shown to be co-localized with β-tubulin on microtubules. At least two isoforms of THEM2 are known to exist.
면역원
THEM2 antibody was raised against a 17 amino acid peptide near the carboxy terminus of human THEM2.
생화학적/생리학적 작용
Acyl-CoA thioesterase 13 (ACOT13)/thioesterase superfamily member 2 (THEM-2) possesses thioesterase activity, with greater activity observed with longer chain acyl-CoAs such as myristoyl- and palmitoyl-CoA. THEM2 associates with StarD, a protein that plays a key role in fatty acid metabolism, and the addition of StarD to THEM2 increased its catalytic activity, suggesting that THEM2 plays a significant role in the metabolism of fatty acids.
특징 및 장점
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결합
The action of this antibody can be blocked using blocking peptide SBP3500070.
물리적 형태
Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.
Deactivating fatty acids: acyl-CoA thioesterase-mediated control of lipid metabolism.
Tillander V, et al.
Trends in Endocrinology and Metabolism, 28(7), 473-484 (2017)
Thioesterase superfamily member 2 (Them2)/acyl-CoA thioesterase 13 (Acot13): a homotetrameric hotdog fold thioesterase with selectivity for long-chain fatty acyl-CoAs.
Jie W, et al.
The Biochemical Journal, 421(2), 311-322 (2009)
Molecular features of the basal-like breast cancer subtype based on BRCA1 mutation status.
Prat A, et al.
Breast Cancer Research and Treatment, 147(1), 185-191 (2014)
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