SAB1410944

Anti-PDK4 antibody produced in rabbit

purified immunoglobulin, buffered aqueous solution

• 동의어(들): FLJ40832
• UNSPSC 코드: 12352203
• NACRES: NA.43

속성

• 생물학적 소스: rabbit
• Quality Level: 100
• 결합: unconjugated
• 항체 형태: purified immunoglobulin
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 형태: buffered aqueous solution
• 분자량: antigen 46.5 kDa
• 종 반응성: human
• 기술: immunofluorescence: suitable; western blot: 1 μg/mL
• NCBI 수납 번호: NM_002612
• UniProt 수납 번호: Q16654
• 배송 상태: dry ice
• 저장 온도: −20°C
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... PDK4(5166)

설명

일반 설명

Pyruvate dehydrogenase kinase isoenzyme 4 (PDK4) is a mammalian mitochondrial serine kinase, encoded by the gene mapped to human chromosome 7q21.3. The encoded protein belongs to the PDK family. PDK4 transcripts are highly expressed in heart and skeletal muscle. It is also expressed at moderate levels in human brain, placenta, lung, liver, kidney and pancreas.

This gene is a member of the PDK/BCKDK protein kinase family and encodes a mitochondrial protein with a histidine kinase domain. This protein is located in the matrix of the mitrochondria and inhibits the pyruvate dehydrogenase complex by phosphorylating one of its subunits, thereby contributing to the regulation of glucose metabolism. Expression of this gene is regulated by glucocorticoids, retinoic acid and insulin. (provided by RefSeq)

면역원

PDK4 (NP_002603.1, 1 a.a. ~ 411 a.a) full-length human protein.

Sequence
MKAARFVLRSAGSLNGAGLVPREVEHFSRYSPSPLSMKQLLDFGSENACERTSFAFLRQELPVRLANILKEIDILPTQLVNTSSVQLVKSWYIQSLMDLVEFHEKSPDDQKALSDFVDTLIKVRNRHHNVVPTMAQGIIEYKDACTVDPVTNQNLQYFLDRFYMNRISTRMLMNQHILIFSDSQTGNPSHIGSIDPNCDVVAVVQDAFECSRMLCDQYYLSSPELKLTQVNGKFPDQPIHIVYVPSHLHHMLFELFKNAMRATVEHQENQPSLTPIEVIVVLGKEDLTIKISDRGGGVPLRIIDRLFSYTYSTAPTPVMDNSRNAPLAGFGYGLPISRLYAKYFQGDLNLYSLSGYGTDAIIYLKALSSESIEKLPVFNKSAFKHYQMSSEADDWCIPSREPKNLAKEVAM

생화학적/생리학적 작용

Pyruvate dehydrogenase kinase isoenzyme 4 (PDK4) catalyzes the phosphorylation of pyruvate dehydrogenase (PDH and also facilitates ATP-dependent inactivation of the PDH complex. Thus, it plays a vital role in glucose utilization and lipid metabolism. Elevated expressions of the protein leads to progressive small vessel loss in pulmonary arterial hypertension (PAH) and reduced endothelial-pericyte interactions. PDK4 is considered to be an emerging therapeutic target for type 2 diabetes.

물리적 형태

Solution in phosphate buffered saline, pH 7.4

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable