S9564

Amyloid Precursor Protein α, Secreted human

>90% (SDS-PAGE), recombinant, expressed in E. coli (N-terminal histidine tagged), buffered aqueous solution

• 동의어(들): sAPPα
• MDL number: MFCD03454663
• UNSPSC 코드: 12352202
• NACRES: NA.32

속성

• 재조합: expressed in E. coli (N-terminal histidine tagged)
• Quality Level: 200
• 분석: >90% (SDS-PAGE)
• 양식: buffered aqueous solution
• 분자량: ~100 kDa by SDS-PAGE
• UniProt 수납 번호: P05067
• 배송 상태: dry ice
• 저장 온도: −70°C
• 유전자 정보: human ... APP(351)

설명

일반 설명

The APP (amyloid precursor protein) gene is mapped to human chromosome 21q21.3.[1] It encodes a integral membrane protein. APPα is a soluble protein generated by sequential cleavage with α and γ secretase.[2]

애플리케이션

Human amyloid precursor protein α secreted, has been used in enzyme linked immunosorbent assay (ELISA).[3][4][5]

생화학적/생리학적 작용

Amyloid precursor protein α is an α-secretase-cleaved soluble protein that has been shown to have neuroprotective properties. It is derived from amyloid precursor protein. The protein consists of 612 amino acids. Several G protein-coupled receptors are known to activate α-secretase-dependent processing of APP. It has neuroprotective, neurogenic and neurotrophic functions. Amyloid precursor protein a also stimulates gene expression and protein expression.[6]

물리적 형태

Solution 0.2 μm filtered, in phosphate buffered saline, pH 7.4.

제조 메모

Expressed as a soluble protein and purified under non-denaturing conditions.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: nwg
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable