모든 사진(3)
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25 MG
₩261,870
100 MG
₩359,716
About This Item
실험식(Hill 표기법):
C27H44O3
CAS Number:
Molecular Weight:
416.64
EC Number:
MDL number:
UNSPSC 코드:
12352200
PubChem Substance ID:
NACRES:
NA.25
추천 제품
분석
≥98%
응용 분야
metabolomics
vitamins, nutraceuticals, and natural products
SMILES string
C[C@H]1CC[C@@]2(OC1)O[C@H]3C[C@H]4[C@@H]5CC[C@@H]6C[C@@H](O)CC[C@]6(C)[C@H]5CC[C@]4(C)[C@H]3[C@@H]2C
InChI
1S/C27H44O3/c1-16-7-12-27(29-15-16)17(2)24-23(30-27)14-22-20-6-5-18-13-19(28)8-10-25(18,3)21(20)9-11-26(22,24)4/h16-24,28H,5-15H2,1-4H3/t16-,17-,18+,19-,20+,21-,22-,23-,24-,25-,26-,27+/m0/s1
InChI key
GMBQZIIUCVWOCD-WWASVFFGSA-N
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일반 설명
Sarsasapogenin also known as Sarsagenin or Parigenin, is a steroidal saponin and is the main constituent of Anemarrhena asphodeloides Bunge.[1]
애플리케이션
Sarsasapogenin has been used as a synthetic saponin treatment to U-2 OS cells to test its effects in reducing osteosarcoma cell viability and down-regulating YAP and TAZ proteins.[2]
생화학적/생리학적 작용
Sarsasapogenin is a well-known multi-target directed ligand (MTDL) for Alzheimer′s disease.[3] It elicits anti-inflammatory, antioxidant, anti-arthritis, anti-asthma, anti-amyloidogenic, neuroprotective, anti-depressant, and anti-cancer properties.[1][3][4] SAR also improves learning and memory ability, loss of neurons in type-1 diabetic rats and protects against diabetic encephalopathy.[1] It is also a therapeutic target for treating ulcerative colitis (UC).[4] SAR as an anti-inflammatory agent improves insulin resistance and adipose tissue inflammation in high-fat diet (HFD)-fed mice.[5]
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, type N95 (US)
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Lot/Batch Number
이미 열람한 고객
Deepa S Mandlik et al.
Immunopharmacology and immunotoxicology, 43(5), 571-583 (2021-08-03)
Ulcerative colitis (UC) is a chronic inflammatory bowel condition considered by oxido-nitrosative stress and the release of pro-inflammatory cytokines that affects the mucosal lining of the colon. Sarsasapogenin (SG), as an active component, has been found in many plants, and
Priya Kashyap et al.
Steroids, 153, 108529-108529 (2019-11-02)
Alzheimer's disease (AD) is multi-factorial disorder characterized by impaired memory and cognition deficit. AD is characterized by impaired cholinergic transmission, extracellular amyloid beta deposits, neurofibrillary tangles and oxidative stress. A multi-target directed ligand (MTDL) approach is required to devise a
Maria Ferraiuolo et al.
Cancer letters, 433, 18-32 (2018-06-23)
Osteosarcoma (OS) is the most aggressive type of primary solid tumor that develops in bone. Whilst conventional chemotherapy can improve survival rates, the outcome for patients with metastatic or recurrent OS remains poor, so novel treatment agents and strategies are
Yan-Yan Yu et al.
Acta pharmacologica Sinica, 42(2), 272-281 (2020-07-24)
Insulin resistance is a major cause of type 2 diabetes and metabolic syndrome. Macrophage infiltration into obese adipose tissue promotes inflammatory responses that contribute to the pathogenesis of insulin resistance. Suppression of adipose tissue inflammatory responses is postulated to increase
Dorota Czajkowska et al.
Steroids, 74(13-14), 1073-1079 (2009-09-15)
Syntheses of "glycospirostanes" from 3beta-hydroxy-23,24-dinor-5alpha-cholano-22,16-lactone and 3alpha-hydroxy-23,24-dinor-5beta-cholano-22,16-lactone were performed. The key step of these syntheses was ring-closing metathesis of the corresponding C,O-diallyl derivative. Further elaboration of the six-membered ring F consisted of allylic hydroxylation with SeO(2) followed by OsO(4) dihydroxylation
활성 필터
자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..
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