PZ0365
CP-376395 hydrochloride
≥98% (HPLC)
동의어(들):
4-Pyridinamine, N-(1-ethylpropyl)-3,6-dimethyl-2-(2,4,6-trimethylphenoxy)-, hydrochloride (1:1), CP376395 hydrochloride, N-(1-Ethylpropyl)-3,6-dimethyl-2-(2,4,6-trimethylphenox y)-4-pyridinamine hydrochloride
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크기 선택
5 MG
₩140,781
25 MG
₩568,806
₩140,781
예상 입고일2025년 5월 28일세부사항
모든 사진(1)
크기 선택
보기 변경
5 MG
₩140,781
25 MG
₩568,806
About This Item
실험식(Hill 표기법):
C21H30N2O · HCl
CAS Number:
Molecular Weight:
362.94
MDL number:
UNSPSC 코드:
12352200
NACRES:
NA.77
₩140,781
예상 입고일2025년 5월 28일세부사항
추천 제품
Quality Level
분석
≥98% (HPLC)
양식
powder
저장 조건
desiccated
색상
white to beige
solubility
DMSO: 2 mg/mL, clear
저장 온도
room temp
SMILES string
CC1=C(NC(CC)CC)C=C(C)N=C1OC2=C(C)C=C(C)C=C2C.[H]Cl
InChI
1S/C21H30N2O.ClH/c1-8-18(9-2)23-19-12-16(6)22-21(17(19)7)24-20-14(4)10-13(3)11-15(20)5;/h10-12,18H,8-9H2,1-7H3,(H,22,23);1H
InChI key
UDIOZDHQQNYISB-UHFFFAOYSA-N
생화학적/생리학적 작용
CP-376395 is a potent and selective antagonist of the CRF1 receptor, which has been shown to play an important role in mediating behavioral and endocrine responses to fear and stress.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
가장 최신 버전 중 하나를 선택하세요:
시험 성적서(COA)
Lot/Batch Number
Jeffrey A Simms et al.
Addiction biology, 19(4), 606-611 (2013-02-01)
Corticotrophin-releasing factor (CRF) is a mediator of stress responses and a key modulator of ethanol-mediated behaviors. We report here that the CRF receptor 1 (CRF-R1) antagonist, CP-376395 reduces 20% ethanol consumption in animals trained to consume ethanol on an intermittent
Yuhpyng L Chen et al.
Journal of medicinal chemistry, 51(5), 1385-1392 (2008-02-22)
An orally active clinical candidate of corticotropin-releasing factor 1 (CRF 1) antagonist 1 showed a significant positive food effect in dog and human after oral administration. Efforts to address the food effect issue led us to explore and discover compounds
Andrew S Dore et al.
Current molecular pharmacology, 10(4), 334-344 (2017-02-12)
The structural analysis of class B G protein-coupled receptors (GPCR), cell surface proteins responding to peptide hormones, has until recently been restricted to the extracellular domain (ECD). Corticotropin-releasing factor receptor type 1 (CRF1R) is a class B receptor mediating stress
활성 필터
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