PZ0198

Prinomastat hydrochloride

≥95% (HPLC)

• 동의어(들): (S)-2,2-Dimethyl-4-((p-(4-pyridyloxy)phenyl)sulfonyl)-3-thiomorpholinecarbohydroxamic acid hydrochloride, AG 3340 hydrochloride, AG-3340 hydrochloride, AG3340 hydrochloride
• 실험식(Hill 표기법): C₁₈H₂₁N₃O₅S₂ · HCl
• CAS Number: 192329-42-3
• Molecular Weight: 459.97
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329823770
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥95% (HPLC)
• 양식: powder
• 저장 조건: desiccated
• 색상: white to beige
• solubility: H₂O: 15 mg/mL (clear solution)
• 저장 온도: room temp
• SMILES string: Cl.CC1(C)SCCN([C@H]1C(=O)NO)S(=O)(=O)c2ccc(Oc3ccncc3)cc2
• InChI: 1S/C18H21N3O5S2.ClH/c1-18(2)16(17(22)20-23)21(11-12-27-18)28(24,25)15-5-3-13(4-6-15)26-14-7-9-19-10-8-14;/h3-10,16,23H,11-12H2,1-2H3,(H,20,22);1H/t16-;/m0./s1
• InChI key: UQGWXXLNXBRNBU-NTISSMGPSA-N

설명

일반 설명

Prinomastat comprises hydroxamic acid group and chelates with zinc ion.[1]

애플리케이션

Prinomastat hydrochloride has been used as an antagonist for metalloproteinases (MMPs) in Crotalus atrox venom samples[2] and mouse embryo cultures.[3] It may be used as a MMP-2 inhibitor in HepG2 cells.[4]

생화학적/생리학적 작용

Prinomastat is a matrix metalloprotease (MMP) inhibitor with selectivity for MMPs 2, 3, 9, 13, and 14. Inhibition of these MMPs has been postulated to block tumor invasion and metastasis. It is extremely potent at MMP-3 and MMP-2 with IC₅₀s, 30 pM & 50 pM, respectively.

Prinomastat is a matrix metalloprotease (MMP) inhibitor.

안전성 정보

• 픽토그램: GHS08
• 신호어: Danger
• 유해 및 위험 성명서: H360
• 예방조치 성명서: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Repr. 1B
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable