P8122
Anti-Potassium Channel KIR3.2 (GIRK2) antibody produced in rabbit
affinity isolated antibody, lyophilized powder
동의어(들):
Anti-BIR1, Anti-GIRK-2, Anti-GIRK2, Anti-KATP-2, Anti-KATP2, Anti-KCNJ7, Anti-KIR3.2, Anti-KPLBS, Anti-hiGIRK2
로그인조직 및 계약 가격 보기
크기 선택
200 μL
₩1,297,069
₩1,297,069
구입 가능 여부는 고객센터에 문의하십시오.
모든 사진(2)
크기 선택
보기 변경
200 μL
₩1,297,069
About This Item
₩1,297,069
구입 가능 여부는 고객센터에 문의하십시오.
추천 제품
생물학적 소스
rabbit
Quality Level
결합
unconjugated
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
양식
lyophilized powder
종 반응성
mouse, rat
기술
western blot: 1:200 using rat brain membranes
UniProt 수납 번호
배송 상태
dry ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... KCNJ6(3763)
mouse ... Kcnj6(16522)
rat ... Kcnj6(25743)
관련 카테고리
일반 설명
G protein-activated inward rectifier potassium channel 2 (GIRK2) is localized on the plasma membrane. It is expressed majorly in the brain and to some extent in the pancreas. The GIRK2 gene is mapped to human chromosome 21q22.13. Structurally, GIRK2 exists as a tetramer and comprises a transmembrane domain and a cytoplasmic domain.
특이성
Anti-Potassium Channel KIR3.2 (GIRK2) recognizesKIR3.2 (GIRK2).
면역원
GST fusion protein with sequence corresponding to residues 374-414 of mouse KIR3.2 (GIRK2). Sequence homology is 40/41, 39/41, and 37/41 residues identical in rat, golden hamster, and human, respectively.
애플리케이션
생화학적/생리학적 작용
G protein-activated inward rectifier potassium channel 2,(GIRK2) plays a key role in γ-aminobutyric acid-ergic (GABAergic), dopaminergic, cholinergic, and glutamatergic synapses. It also regulates neuronal excitability. GIRK2 through G protein-coupled receptor stimulation modulates neuronal circuit activity and heart rate in cardiac cells. Deletion of the GIRK2 gene in mice may lead to an anxiety-like phenotype and a depression-resistant behavior.
물리적 형태
Lyophilized powder from phosphate buffered saline containing 1% bovine serum albumin and 0.05% sodium azide.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
13 - Non Combustible Solids
WGK
WGK 2
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
Chella Kamarajan et al.
International journal of psychophysiology : official journal of the International Organization of Psychophysiology, 115, 13-23 (2016-12-21)
Event related oscillations (EROs) are heritable measures of neurocognitive function that have served as useful phenotype in genetic research. A recent family genome-wide association study (GWAS) by the Collaborative Study on the Genetics of Alcoholism (COGA) found that theta EROs
Nerea Llamosas et al.
The international journal of neuropsychopharmacology, 18(11), pyv051-pyv051 (2015-05-10)
Targeting dorsal raphe 5-HT1A receptors, which are coupled to G-protein inwardly rectifying potassium (GIRK) channels, has revealed their contribution not only to behavioral and functional aspects of depression but also to the clinical response to its treatment. Although GIRK channels
S Kumar et al.
Anaesthesia, 74(11), 1456-1470 (2019-08-28)
Advances in the field of pharmacogenomics have resulted in the discovery of some important single-nucleotide polymorphisms which are found to be associated with opioid dose variability. This, to a large extent, explains genetic variability in the analgesic dose of opioids.
Matthew R Whorton et al.
Cell, 147(1), 199-208 (2011-10-04)
G protein-gated K(+) channels (Kir3.1-Kir3.4) control electrical excitability in many different cells. Among their functions relevant to human physiology and disease, they regulate the heart rate and govern a wide range of neuronal activities. Here, we present the first crystal
Sinead M Clancy et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 27(24), 6388-6399 (2007-06-15)
Many inhibitory neurotransmitters in the brain activate Kir3 channels by stimulating pertussis toxin (PTX)-sensitive G-protein-coupled receptors. Here, we investigated the regulation of native muscarinic receptors and Kir3 channels expressed in NGF-differentiated PC12 cells, which are similar to sympathetic neurons. Quantitative
활성 필터
자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..
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