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Merck
모든 사진(3)

문서

P7762

Sigma-Aldrich

Poly-L-arginine hydrochloride

mol wt 15,000-70,000

동의어(들):

L-Arginine homopolymer hydrochloride

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모든 사진(3)

About This Item

CAS Number:
26982-20-7
MDL number:
MFCD00166393
UNSPSC 코드:
12352209
PubChem Substance ID:
24898874
NACRES:
NA.26

형태

powder

분자량

15,000-70,000

색상

white to off-white

응용 분야

cell analysis

저장 온도

−20°C

SMILES string

Cl.NC(CCCNC(N)=N)C(O)=O

InChI

1S/C18H38N12O4.ClH/c19-10(4-1-7-26-16(20)21)13(31)29-11(5-2-8-27-17(22)23)14(32)30-12(15(33)34)6-3-9-28-18(24)25;/h10-12H,1-9,19H2,(H,29,31)(H,30,32)(H,33,34)(H4,20,21,26)(H4,22,23,27)(H4,24,25,28);1H/t10-,11-,12-;/m0./s1

InChI key

PQEISBBDIRAKGR-LFELFHSZSA-N

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관련 카테고리

일반 설명

Poly-L-arginine hydrochloride (PLA) is a homopolyamino acid. PLA enhances membrane permeability compared to poly-L-lysine. It has applications as drug carrier, neuroprotective agent and in anticancer vaccines preparations. Peptide vaccines in conjugation with PLA promotes antigen-presenting cells (APCs) to generate T cell and elicit immunostimulant functionality.

애플리케이션

Poly-L-arginine hydrochloride has been used:
  • to generate complex with stimulatory RNA isRNA9.2 as in neutrophils
  • used in ribosomal RNA transfection into human monocytic THP-1 cells
  • for coating alginate capsule beads

품질

Contains 3% or less ornithine residue.

분석 메모

Molecular weight based on viscosity of precursor poly-L-ornithine. Also assayed by MALLS.

기타 정보

For additional technical information on polyamino acids please visit the Polyamino acid FAQ resource.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)

시험 성적서(COA)

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문서 라이브러리 방문

RNA of Enterococcus faecalis strain EC-12 is a major component inducing interleukin-12 production from human monocytic cells
Nishibayashi R, et al.
PLoS ONE, 10(6), e0129806-e0129806 (2015)
Neutrophils express distinct RNA receptors in a non-canonical way
Berger M, et al.
The Journal of Biological Chemistry, 287(23), 19409-19417 (2012)
Kotaro Sakamoto et al.
Frontiers in pharmacology, 12, 751587-751587 (2021-11-26)
Worldwide, more than 20 million people suffer from schizophrenia, but effective and definitive new therapeutic drugs/treatments have not been established. Vasoactive intestinal peptide receptor 2 (VIPR2) might be an attractive drug target for the treatment of schizophrenia because both preclinical and
Antibacterial activity of poly-l-arginine under different conditions
Sepahi M , et al.
Iranian Journal of Microbiology, 9(2), 103-103 (2017)
Vaccination with poly-L-arginine as immunostimulant for peptide vaccines: induction of potent and long-lasting T-cell responses against cancer antigens
Mattner F, et al.
Cancer Research, 62(5), 1477-1480 (2002)
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