P4380

Protamine sulfate

powder

• 동의어(들): Salmine, Salmine from salmon
• CAS Number: 53597-25-4
• MDL number: MFCD00132091
• UNSPSC 코드: 12352202
• NACRES: NA.77

속성

• 제품명: Protamine sulfate salt from salmon, Grade II
• 생물학적 소스: fish (salmon)
• Quality Level: 200
• 유형: Grade II
• 양식: powder
• 색상: white to off-white
• solubility: 6 M HCl: 25 mg/mL, clear, colorless to light yellow

설명

일반 설명

Protamine sulfate (PS), a polycationic, positively charged protein[1] is mostly made up of poly(l-arginine).[2] It is obtained from salmon sperm protein.[1]

애플리케이션

May be used for the removal of DNA from protein samples or for the purification of DNA binding proteins. It may be used as an alternative to polybrene in retroviral-mediated gene transfer.

Protamine in the form of solid lipid nanoparticles (SLN) promoted transfection with plasmid DNA more efficiently and with less cytotoxicity than comparable SLNs composed of Esterquat-1.

Protamine in the form of solid lipid nanoparticles (SLN) promoted transfection with plasmid DNA more efficiently and with less cytotoxicity than comparable SLNs composed of Esterquat-1.

Protamine sulfate salt from salmon has been used in the generation of protamine silica nanocomposites.[3]

생화학적/생리학적 작용

Protamine sulfate is a small cationic protein that binds and precipitates DNA. Neutralizes the anticoagulant activity of heparin. Inhibits lipoprotein lipase.

Protamine sulfate is highly preferred in cardiovascular surgical procedures to reverse the anticoagulant properties of heparin.[4] It is used for biomedical and biotechnological applications due to its biodegradablity.[2]

품질

May contain insolubles as well as histones.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)