p53 is a tumor suppressor gene expressed in a wide variety of tissues. It is a tetrameric nuclear DNA-binding phosphoprotein. The gene encoding it is localized on human chromosome 17p13.1 and mouse chromosome 11.
면역원
GST fusion protein of human p53 corresponding to amino acids 1-393.
애플리케이션
Monoclonal Anti-p53-Biotin antibody produced in mouse has been used for Western Blotting.
생화학적/생리학적 작용
Tumor suppressor p53 has the capability to induce cell cycle arrest and has a role in DNA repair, senescence and apoptosis. It binds to Simian vacuolating virus 40 (SV40) T-antigen and human papilloma virus E6 protein. The p53 gene is mutated in various cancers, such as of the breast, ovarian, bladder, colon and lung.
물리적 형태
Solution in 0.01 M phosphate buffered saline, containing 0.08% sodium azide.
면책조항
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