P0036
PP121
≥98% (HPLC)
동의어(들):
1-cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
로그인조직 및 계약 가격 보기
크기 선택
5 MG
₩331,296
₩331,296
구입 가능 여부는 고객센터에 문의하십시오.
모든 사진(1)
크기 선택
보기 변경
5 MG
₩331,296
About This Item
실험식(Hill 표기법):
C17H17N7
CAS Number:
Molecular Weight:
319.36
MDL number:
UNSPSC 코드:
12352200
PubChem Substance ID:
NACRES:
NA.77
₩331,296
구입 가능 여부는 고객센터에 문의하십시오.
추천 제품
Quality Level
분석
≥98% (HPLC)
양식
powder
색상
off-white
solubility
DMSO: >10 mg/mL
저장 온도
2-8°C
SMILES string
Nc1ncnc2n(nc(-c3cnc4[nH]ccc4c3)c12)C5CCCC5
InChI
1S/C17H17N7/c18-15-13-14(11-7-10-5-6-19-16(10)20-8-11)23-24(12-3-1-2-4-12)17(13)22-9-21-15/h5-9,12H,1-4H2,(H,19,20)(H2,18,21,22)
InChI key
NVRXTLZYXZNATH-UHFFFAOYSA-N
생화학적/생리학적 작용
PP121 blocks the vascular endothelial growth factor (VEGF) receptor and its related signaling events.[1] It also inhibits tumor cell proliferation by targeting oncogenic tyrosine kinase and phosphoinositide 3-kinases (PI3Ks).[1]
PP121 is a dual inhibitor of tyrosine and phosphoinositide kinases.
PP121 is a dual inhibitor of tyrosine and phosphoinositide kinases. PP121 is the first inhibitor active on both Tyrosine kinases and the phosphatidylinositol-3-OH kinase (PI(3)K) family. The inhibitor is not effecting other serine-threonine protein kinases.
특징 및 장점
This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Phosphoinositide Kinases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
가장 최신 버전 중 하나를 선택하세요:
Beth Apsel et al.
Nature chemical biology, 4(11), 691-699 (2008-10-14)
The clinical success of multitargeted kinase inhibitors has stimulated efforts to identify promiscuous drugs with optimal selectivity profiles. It remains unclear to what extent such drugs can be rationally designed, particularly for combinations of targets that are structurally divergent. Here
Zhihang Zhou et al.
Experimental cell research, 388(2), 111857-111857 (2020-01-24)
Bone resorption, caused by osteoclasts (OCs), is important to bone homeostasis. The abnormalities of bone resorption may induce a series of diseases, including osteoarthritis, osteoporosis and aseptic peri-implant loosening. The latest research developed,a novel tyrosine and phosphoinositide kinase dual inhibitor
문서
Discover Bioactive Small Molecules for Kinase Phosphatase Biology
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