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Merck
모든 사진(2)

주요 문서

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N8784

Sigma-Aldrich

Norcantharidin

solid

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모든 사진(2)

About This Item

실험식(Hill 표기법):
C8H8O4
CAS Number:
29745-04-8
Molecular Weight:
168.15
MDL number:
MFCD00213361
UNSPSC 코드:
12352202
PubChem Substance ID:
24278599
NACRES:
NA.77

양식

solid

SMILES string

O=C1OC(=O)C2C3CCC(O3)C12

InChI

1S/C8H8O4/c9-7-5-3-1-2-4(11-3)6(5)8(10)12-7/h3-6H,1-2H2

InChI key

JAABVEXCGCXWRR-UHFFFAOYSA-N

유전자 정보

human ... PPP2R5A(5525)

일반 설명

Norcantharidin (NCTD) is a demethylated derivative of cantharidin (CTD).[1]

애플리케이션

Norcantharidin has been used in primary cell culture and treatment.[2] It has also been used to treat mice inoculated with Huh7 cells subcutaneously.[3]

생화학적/생리학적 작용

Norcantharidin is a potential antitumor agent. Norcantharidin helps to block SK-N-SH neuroblastoma cell growth by stimulating autophagy and apoptosis.[1]

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)

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시험 성적서(COA)

Lot/Batch Number
101K1371

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문서 라이브러리 방문

Chao-Bin Yeh et al.
PloS one, 7(2), e31055-e31055 (2012-03-01)
The rate of morbidity and mortality of hepatocellular carcinoma (HCC) in Taiwan has not lessened because of difficulty in treating tumor metastasis. Norcantharidin (NCTD) is currently used as an anticancer drug for hepatoma, breast cancer, and colorectal adenocarcinoma. NCTD possesses
C Y Hong et al.
Biochemical and biophysical research communications, 276(1), 278-285 (2000-09-28)
Norcantharidin (NCTD), a synthetic analogue of phosphatase type 2A inhibitors, cantharidin, was shown to have limited effects in treating human and animal tumors. The tumor cell killing mechanisms by norcantharidin, however, remain unclear. In this report, we wished to investigate
Norcantharidin modulates the miR-30a/Metadherin/AKT signaling axis to suppress proliferation and metastasis of stromal tumor cells in giant cell tumor of bone
Chen F, et al.
Biomedicine and Pharmacotherapy, 103, 1092-1100 (2018)
Norcantharidin inhibits SK-N-SH neuroblastoma cell growth by induction of autophagy and apoptosis
Han Z, et al.
Technology in Cancer Research & Treatment, 16(1), 33-44 (2017)
Rebekah E Wharton et al.
Toxins, 11(12) (2019-12-19)
Microcystins (MC) and nodularin (NOD) are toxins released by cyanobacteria during harmful algal blooms. They are potent inhibitors of protein phosphatases 1 and 2A (PP1 and PP2A) and cause a variety of adverse symptoms in humans and animals if ingested.
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