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Merck
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문서

MAK246

Sigma-Aldrich

Neutrophil Elastase Activity Assay Kit (Fluorometric)

sufficient for 100 fluorometric tests

동의어(들):

Elastase Enzyme Activity Fluorescent Kit

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About This Item

UNSPSC 코드:
12161503
NACRES:
NA.25

검출 방법

fluorometric

관련 질환(들)

hematological disorder; pulmonary disorders

저장 온도

−20°C

일반 설명

Neutrophil Elastase (NE, EC 3.4.21.37, leukocyte elastase, ELANE, ELA2, elastase 2, neutrophil elaszym, or serine elastase) is a cytotoxic serine protease. It is stored in the azurophil granules of neutrophil granulocyte and is released following cell stimulation, e.g. by pathogens, immune complexes or chemotactic agents (PMA). Mutation in the gene ELA2 (neutrophil elastase) results in neutropenia, a hereditary disorder characterized by reduced neutrophil count in an individual.

애플리케이션


  • Relationship between airway inflammation and airflow limitation in elderly asthmatics.: This study investigates the connection between airway inflammation and airflow limitation in elderly asthmatic patients. It highlights the role of neutrophil elastase in airway inflammation, which was measured using the Neutrophil Elastase Activity Assay Kit (Fluorometric). The findings suggest that targeting neutrophil elastase activity could help in managing airflow limitation in elderly asthmatics, offering potential therapeutic applications for the assay kit (Soma et al., 2020).

적합성

Suitable to determine the activity of purified Neutrophil Elastase, detect the activity of Neutrophil Elastase in plasma and/or blood and screen/study/characterize chemotactic agents causing Neutrophil stimulation and release of Elastase.

원리

The Neutrophil Elastase Activity Assay Kit utilizes the ability of NE to proteolytically cleave a synthetic substrate and release a fluorophore, AFC, which can be easily quantified by fluorescence. This assay kit is simple, rapid, and can detect as low as 1 ng of neutrophil elastase in a variety of samples.

픽토그램

Health hazardExclamation mark
GHS08,GHS07

신호어

Danger

유해 및 위험 성명서

H315,H319,H334,H335

Hazard Classifications

Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - STOT SE 3

표적 기관

Respiratory system

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

시험 성적서(COA)

제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.

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문서 라이브러리 방문

Neutrophil elastase in cyclic and severe congenital neutropenia.
Horwitz M S, et al.
Blood, 109(5), 1817-1824 (2007)
Sang-Il Han et al.
Bioresource technology, 302, 122791-122791 (2020-01-26)
The effect of co-cultivation of Porphyridium cruentum UTEX 161 with Pseudoalteromonas sp. MEBiC 03485 on P. cruentum growth and its sulfated polysaccharide (EPS) production were examined. The strain MEBiC 03485 had beneficial effects on P. cruentum growth, EPS production, and

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