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Merck
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M9440

Sigma-Aldrich

Methyl-3,4-dephostatin

>98% (HPLC), powder

동의어(들):

3,4-Dihydroxy-N-methyl-N-nitrosoaniline

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크기 선택

1 MG
₩302,369

₩302,369

구입 가능 여부는 고객센터에 문의하십시오.
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모든 사진(1)

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1 MG
₩302,369

About This Item

실험식(Hill 표기법):
C7H8N2O3
CAS Number:
173043-84-0
Molecular Weight:
168.15
MDL number:
MFCD01076450
UNSPSC 코드:
12352200
PubChem Substance ID:
24278575
NACRES:
NA.77

₩302,369

구입 가능 여부는 고객센터에 문의하십시오.
벌크 견적 요청

분석

>98% (HPLC)

양식

powder

색상

red-brown

solubility

DMSO: soluble 18 mg/mL
H2O: insoluble

저장 온도

2-8°C

SMILES string

CN(N=O)c1ccc(O)c(O)c1

InChI

1S/C7H8N2O3/c1-9(8-12)5-2-3-6(10)7(11)4-5/h2-4,10-11H,1H3

InChI key

XAKAQCMEMMZUEO-UHFFFAOYSA-N

유전자 정보

human ... PTPN1(5770)

애플리케이션

Methyl-3,4-dephostatin has been used as:
  • an inhibitor for methyltransferases[1]
  • a kinase-related inhibitor for human transglutaminase[2]
  • a cysteine binding compound for screening its effect on C-terminal domain (CTD) of human immunodeficiency virus (HIV-1) capsid protein[3]

생화학적/생리학적 작용

Methyl-3,4-dephostatin is a tyrphostin-related compound isolated from Streptomyces MJ742-NF5 strain.[4] It favors nerve growth factor-based neurite formation in pheochromocytoma PC12 cells.[5] Being a stable analog of the nitrosoaniline dephostatin, it can mimic phosphotyrosine substrate for Tyrosyl-DNA phosphodiesterase I (TdpI).[6]
Stable analog of dephostatin; selective protein tyrosine phosphatase 1B and SHPTP-1 inhibitor; does not inhibit CD45-associated phosphatases.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)

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시험 성적서(COA)

Lot/Batch Number
042K4605

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문서 라이브러리 방문

Ebselen, a small-molecule capsid inhibitor of HIV-1 replication
Thenin-Houssier S, et al.
Antimicrobial Agents and Chemotherapy, 60(4), 2195-2208 (2016)
Thung-S Lai et al.
Chemistry & biology, 15(9), 969-978 (2008-09-23)
Human tissue transglutaminase (TGM2) is a calcium-dependent crosslinking enzyme involved in the posttranslational modification of intra- and extracellular proteins and implicated in several neurodegenerative diseases. To find specific inhibitors to TGM2, two structurally diverse chemical libraries (LOPAC and Prestwick) were
S Fujiwara et al.
Biochemical and biophysical research communications, 238(1), 213-217 (1997-09-23)
We studied the effect of the 3,4-dihydroxy analogue of dephostatin (3,4-dephostatin), an inhibitor of protein-tyrosine phosphatase (PTPase), on the differentiation of rat pheochromocytoma PC12 cells. 3,4-Dephostatin accelerated NGF-induced neurite formation in PC12h cells, a subline of PC12 cells, whereas the
A high throughput scintillation proximity imaging assay for protein methyltransferases
Ibanez G, et al.
Combinatorial Chemistry & High Throughput Screening, 15(5), 359-371 (2012)
T Watanabe et al.
The Journal of antibiotics, 48(12), 1460-1466 (1995-12-01)
We have synthesized derivatives of dephostatin, a protein tyrosine phosphatase (PTPase) inhibitor, to study the structure-activity relationships of this inhibitor. Inactive analogs revealed some insight into structural requirements or PTPase inhibitory activity of dephostatin. Both a nitroso group and phenolic
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