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Merck
모든 사진(5)

문서

M8131

Sigma-Aldrich

α-Methyl-L-tyrosine

≥98% (TLC)

동의어(들):

L-2-Methyl-3-(4-hydroxy­phenyl)alanine, L-AMPT

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모든 사진(5)

About This Item

실험식(Hill 표기법):
C10H13NO3
CAS Number:
672-87-7
Molecular Weight:
195.22
Beilstein:
2368400
EC Number:
211-599-5
MDL number:
MFCD00064201
UNSPSC 코드:
12352200
PubChem Substance ID:
24278155
NACRES:
NA.32

분석

≥98% (TLC)

형태

powder

저장 온도

−20°C

SMILES string

C[C@](N)(Cc1ccc(O)cc1)C(O)=O

InChI

1S/C10H13NO3/c1-10(11,9(13)14)6-7-2-4-8(12)5-3-7/h2-5,12H,6,11H2,1H3,(H,13,14)/t10-/m0/s1

InChI key

NHTGHBARYWONDQ-JTQLQIEISA-N

유전자 정보

human ... TH(7054)

유사한 제품을 찾으십니까? 방문 제품 비교 안내

애플리케이션

α-Methyl-L-tyrosine has been used as an inhibitor tyrosine hydroxylase:
  • to test its effect during acute stress in zebrafish
  • in cannabinoid receptor type-1 (CB1) knockout and wild type mice, to test its effect on norepinephrine turnover
  • to test catecholamines depletion on stress in rat spleen samples
  • to block dopamine synthesis in dopaminergic neurons

α-Methyl-L-tyrosine is used to determine whether Fe2/ methamphetamine (METH) -induced cell death is dependent on cytosolic dopamine and iron mediated oxidative stress.

생화학적/생리학적 작용

α-Methyl-L-tyrosine (L-AMPT) acts as a competitive inhibitor of tyrosine hydroxylase and inhibits the conversion of tyrosine to L-DOPA and eventually lowers dopamine synthesis in cytosol. AMPT at low concentrations can be used as a potent therapeutic for refractory dystonia or dyskinesia. It also helps in decreasing catecholamine concentration in pheochromocytoma patients.
Tyrosine hydroxylase inhibitor.

기타 정보

Active isomer

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)

시험 성적서(COA)

제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.

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문서 라이브러리 방문

Renan Idalencio et al.
General and comparative endocrinology, 252, 236-238 (2017-07-19)
In this article, we show that the tyrosine hydroxylase inhibitor α-Methyl-l-tyrosine (AMPT) decreased the responsiveness of the zebrafish stress axis to an acute stressful challenge. These effects were specific for responses to stimulation, since unstimulated (basal) cortisol levels were not
Low dose alpha-methyl-para-tyrosine (AMPT) in the treatment of dystonia and dyskinesia.
Ankenman R and Salvatore MF
The Journal of Neuropsychiatry and Clinical Neurosciences, 19(1), 65-69 (2007)
Sergio Ortiz-Padilla et al.
Neuropharmacology, 166, 107920-107920 (2019-12-25)
Dopaminergic neurons have the ability to release Dopamine from their axons as well as from their soma and dendrites. This somatodendritically-released Dopamine induces an autoinhibition of Dopaminergic neurons mediated by D2 autoreceptors, and the stimulation of neighbor GABAergic neurons mediated
Raj Kamal Srivastava et al.
International journal of molecular sciences, 23(20) (2022-10-28)
High-calorie diets and chronic stress are major contributors to the development of obesity and metabolic disorders. These two risk factors regulate the activity of the sympathetic nervous system (SNS). The present study showed a key role of the cannabinoid type
Progressive degeneration of human mesencephalic neuron-derived cells triggered by dopamine-dependent oxidative stress is dependent on the mixed-lineage kinase pathway.
Lotharius J
The Journal of Neuroscience, 25(27), 6329-6342 (2005)
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