Each vial contains approximately 2.5 mg protein. The minimum protein concentration is 2.5 mg/mL. A survey of recent lots indicates a consistent concentration of 5.0 mg/mL. The minimum activity of this enzyme is 1 unit per milligram and varies considerably from lot to lot. This value is reported in the product Certificate of Analysis. Please see the link below to review a sample or lot-specific Certificate:
https://www.sigmaaldrich.com/product/sigma/m7441#product-documentation
추천 제품
재조합
expressed in baculovirus infected BTI insect cells
Quality Level
양식
liquid
enzyme activity
≥1 U/mg
포장
vial of ~2.5 mg
UniProt 수납 번호
배송 상태
dry ice
저장 온도
−70°C
유전자 정보
human ... MAOB(4129)
일반 설명
Monoamine Oxidase B is a mitochondrial outermembrane flavoenzyme that is a target for antidepressant and neuroprotective drugs. [1]
애플리케이션
Drugs that inhibit monoamine oxidase B activity are used for the treatment of various neurological disorders including depression. [2]
생화학적/생리학적 작용
MAO′s are proteins of the mitochondrial membrane. These enzymes are responsible for catalyzing oxidative deamination of endo- and xenobiotic amines. Substrate specificity differs for each isozyme.
단위 정의
kynuramine deamination activity: One unit will deaminate 1 nanomole of kynuramine per minute at pH 7.4 at 37 deg C.
관련 제품
제품 번호
설명
가격
Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 1
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
가장 최신 버전 중 하나를 선택하세요:
시험 성적서(COA)
Lot/Batch Number
이미 열람한 고객
K N Westlund et al.
Neuroscience, 25(2), 439-456 (1988-05-01)
Monoclonal antibodies, specific for either monoamine oxidases A or B, were used to determine the localization of monoamine oxidase in the human brain. Two distinct populations of neurons were detected by immunocytochemical staining. Neurons in regions rich in catecholamines were
The effect of age on the activity and molecular properties of human brain monoamine oxidase
Fowler, C., et al.
Journal of Neural Transmission. General Section, 49, 1-20 (1980)
Structure of human monoamine oxidase B, a drug target for the treatment of neurological disorders
Binda, C., et al.
Nature Structural Biology, 9, 22-26 (2001)
Aiko Ishiki et al.
Acta neuropathologica communications, 6(1), 53-53 (2018-07-01)
Recent positron emission tomography (PET) studies have demonstrated the accumulation of tau PET tracer in the affected region of progressive supranuclear palsy (PSP) cases. To confirm the binding target of radiotracer in PSP, we performed an imaging-pathology correlation study in
Dorota Łażewska et al.
Molecules (Basel, Switzerland), 26(12) (2021-07-03)
Neurodegenerative diseases, e.g., Alzheimer's disease (AD), are a key health problem in the aging population. The lack of effective therapy and diagnostics does not help to improve this situation. It is thought that ligands influencing multiple but interconnected targets can
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